I have mild lymphedema and lupus. I take a shot once a month of depo medrol for my pain and have found that it takes down the swelling in my legs. If I go over my month it starts swelling again. I also have a condition called Lipodermatosclerosis where the skin hardens around my ankles and now is starting up my shin bones which makes even mild swelling very painful. I know that predisone does shorten your life span and always said I would never do it but there comes a time when quality over quantity does make a difference. I am facing knee surgery. My knees are completely gone and I am facing knee replacement. I am really a little apprehensive.