I am a 45 YO woman who's father died of APS and Lupus. It was not dignosed for 17 years and many of the symptoms were treated as other diseases. I have been diagnosed with Marginal Zone Splenic Lymphoma with strange infarcs (blood clots) on a giant spleen. Bone marrow biopsy reflected abnormal B-cells so that led to lymphoma diagnosis. Also receiving warfarin as a precaution as a results of those infarcs. Recent bloodwork has reflected both antiphospholipid and Lupus antibodies at different times. Prior to this event was never tested for APS. Both were detected prior to chemo. Doctors (oncologist and rheumatologist)say that bloodwork may be false positives due to the large spleen/lymphoma. After warfarin and 1 round of chemo spleen shrunk to apparently original size. So no way to know if it was the warfarin disolving clots or the chemo. Have had two rounds of chemo and both times doctors are suprised by how I react to the treatment. My question: Can APS mimic lymphoma? Am I being treated for cancer when I really have APS? My doctors all are minimizing the possibilty of APS but am thinking that they do not want to change diagnosis as that would open them up to questions of misdiagnosis. Am not getting good answers and doctors keep changing their stories. Thoughts?