I have been on Coumadin since 2003 and was diagnosed with APS (positive for both types of antibodies) formally in 2010. In 2011, I had, what I and my doctors believe was, a nasty APS flare after my INR mysteriously dropped to .9 despite being on my regular Coumadin dosage. Since that time, I feel that my health has not been the same. This is confounded by an ongoing battle with Metabolic Syndrome, which I am correctly through diet and lifestyle changes.
Anyhow, my Rheumatologist now wants me on Plaqenil. She told me that although the Coumadin thins my blood, it does nothing to address the activity of the antibodies themselves. I don't want to take any immunosuppressant drugs, and I am unclear as to what Plaqenil does and its long-term side effects.
To me, it seemed strange that my doctors have been satisfied with managing my APS with Coumadin alone since 2003, but suddenly want to add another drug. To be honest, I smelled a conflict of interest (some docs get commissions from drug companies for prescribing their drugs).
MY QUESTION IS THE FOLLOWING: DO THE APS ANTIBODIES HAVE ANY EFFECTS BEYOND THE CLOTTING ISSUE?
This is sort of in line with one of my previous questions: are antibodies always present and active or are they ever "dormant."
Do the APS antibodies do damage even when you are controlling the clotting of your blood? If so, what are they doing and how serious is their impact? I mean, we have phospholipids throughout our bodies and they are in all cell membranes. So is it possible that an APS patient on Coumadin only would be controlling the possibility of a clot happening, yet be ignoring a range of other impacts that the antibodies might be having? Thanks a ton.