Pradaxa (Dabigatran) V's Warfarin

Hi all

Just wondering if anyone has made the switch from Warfarin to Pradaxa? My GP says I could be a candidate for it and it could be more advantageous for me given my age and rather than having to monitor INR's all the time. I have APLS and SLE and have been on warfarin + plaquenil since 2005. Wondering if it has worked for you? Benefits and are have you had any bad side effects? Do you think it is too new a drug to take the chance in switching?

Thanks for your help


9 Replies

  • Hi, it is good your GP is thinking about what is best for you, and will he involve your main Hughes Syndrome/APS consultant with this decision, hopefully they will swap letters? MaryF

  • As Mary has said its good they are looking at all options but would point out that the only oral anticoagulant that has so far been approved for use with APS apart from warfarin of course is rivaroxaban and that is for use with people who have had a venus clot only and would have a INR 2-3.

    If you have had an arterial clot and need a higher INR then your options are limited and Im afraid they should only be looking at warfarin or LMWH at this stage. Hope that proves helpful.

  • yes I have had 2 x DVTs (first in 1999 after taking the OCP). Diagnosed with APS and they gave me the choice to take warfarin or low dose aspirin only. I chose the aspirin only option at the time because I was only 28 and was fairly active. I went 6 years but then got the 2nd DVT. So now its warfarin for life! I haven't heard of Rivaroxaban so will look into that one!

    Thanks for your help.


  • Hi, I guess you live in England.

    In that case it could be possible for you to selftest if you find it difficult to stay steady and in the therapeutic INR-value. Also LMW Heparin if you must have an INR between 3.0 - 4.0.

    Ask your Specialist about arterial and venous clots and if you can not be on Rivaroxaban you could ask for selftesting. Many members like me do it with good result. I am primary APS so I do not know much about SLE and Plaquenil.

    Best wishes from Kerstin in Stockholm

  • Hi Kerstin,

    No Iam actually in Australia, and have my own INR machine (Coaguchek) which I have been using for the last 5 years or so. The SLE only reared its ugly head when I fell pregnant and post pregnancy. It seems to be under control - touch wood with the plaquenil.

  • Hi from another Aussie. I've been on Rivaroxaban for nearly two years now. The only downside with NOAC's is if you're needing surgery and to have appropriate bridging. I also take 100mg Aspirin. I have been doing a lot of reading and asking lots of questions when I see the doctors looking after me. The on thing they do impress upon you is that the medication should be taken at the same time daily.

  • I do not take Pradaxa but the only issue I have read or heard from people on this anticoagulant is that for some it tends to cause tummy upset and indigestion. I am on Eliquis which as they say has not been approved for APS. However, I am clot free and doing the best I can with this disorder. Hope this new change works out for you.


  • I moved from warfarin (my INR would never regulate) to enoxaparin (on which I suffered numerous internal bleeds while still having TIAs) then to dabigatrin (which has been a godsend - no bleeds, no TIAs, for about 3 years). I highly recommend the latter. Doug

  • Thanks everyone! I'll have to see my immunologist and see what he thinks about the switch first I guess!

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