I'm 44 and was diagnosed with APS in July this year. I have been on warfarin and hydroxy chloroquine for a connective tissue disorder since then. However, my INR is not stable, it gets up to 2.2 for a week or two then drops to 1.7. My dose has steadily risen to 7/6mg alt days. Is this normal? I'm worried my dose will have to keep going up, does this happen a lot?