I am looking for a centre of excellence in the UK NHS or Private to do advanced coeliac testing . My boys & I have Polyglandular autoimmune disease ( which covers a number of conditions & we have many of the conditions ) One child has coeliac disease & I wish to confirm
as far as I can that the other child does or doesn't ( including subclinical )
Recommended Blood Tests:
Anti-tissue transglutaminase antibody (tTG – IgA and IgG) Yes available
commonly used whether or not symptoms are present and the most sensitive test available
Anti-endomysial antibody (EMA-IgA) – highly specific marker for celiac disease Yes available
*******Anti-deaminated gliadin peptide (DGP – IgA and IgG)********* LOOKING FOR
used when tTG or EMA is negative and in cases where patient is IgA deficient
Total serum IgA – used to check levels to exclude selective IgA deficiency that results in a false negative test
AGAs IgG - LOOKING FOR
Anti-gliadin antibody (AgA – IgG and IgA) YES available
not considered sensitive or specific enough for adults, but used for children under 2 because tTG and EMA antibodies may be absent. The anti-DGP test is sensitive in this group.
Any ideas ????