ABPA : Recently diagnosed with ABPA... - Aspergillosis and...

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ABPA

4 years ago•4 Replies

Recently diagnosed with ABPA. IGE is not very high, had history of asthma, when i was young. I was on antifungal vericonazole 200 mg bd for one month and then alternate day. For 2 minths. I am diabetic as well. Steroid on inhalation and eiosinophilia (10 to 20%). Symtoms were better after initial course of vericonazole. Again started after 3 months of stopping medication. Started again. It responds to only antifungsl. Steroid aline does not jave much impact. It may be eiosinophilic lung disease as well as. Trying to find out reasons for high eiosinophil count. It may be drug induced, parasitic infection or fungal sensitisation (ABPA). Waiting for antifungal inhaler (suppose to come in 2021).trying different things.

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suraksha69

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GAthertonAdministratorFungal Infection Trust4 years ago

Antifungal meds are useful to control exacerbations and to try to reduce the dose of oral steroids you are taking. I would question the wisdom of going on to half a dose of voriconazole (ie alternate days) as to me that would lower the effective dose, potentially below the therapeutic window and encourage the buildup of antifungal drug resistance in the fungi who are growing in your airways. It might be worth questioning your doctor over that !

suraksha69 in reply to GAtherton4 years ago

Complete eradication usually occurs in one or two month, however recurrent fungal growth may need intermittent dose. ( I May not be right completely). Antifungal has high side effects. My liver funtion and ggt is already compromised. What do you suggest? I am an anesthesiologist. When to stop antifungal? Instead of alternate dose, do you suggest every month 10 days course?

GAthertonAdministratorFungal Infection Trust in reply to suraksha693 years ago

I am not a medical doctor Suraksha so I cannot give you specific medical advice. I know our patients might be given a different antifungal drug if they fail to tolerate one but that decision is for your doctors to make.

suraksha69 in reply to GAtherton4 years ago

What may be time patients should go for vericonazole countinously? Will be thankful if you can guide

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