ASCO GU 2025: first randomized trial about gut microbiome and prostate cancer

[Maxone73]

Here we go...because diet and microbiome are not important someone said... 😜😜

A randomized clinical trial investigated how a phytochemical-rich food supplement, with or without a probiotic/prebiotic blend, affects prostate cancer progression.

All 212 men, averaging 74.5 years old, received the supplement (ginger, cranberry, pomegranate, turmeric, broccoli, green tea).

Half also took a blend of lactobacillus probiotics, inulin, and vitamin D; half received placebo.

Those on the supplement alone saw a drop in their PSA growth rate from 19.6% to 6.2%.

Men who added probiotics went from a 21.7% PSA rise to a 20% reduction—a 41.7% swing.

They also reported better urinary symptom scores and improved erectile function.

MRI scans showed stabilization or shrinkage of disease in most patients, with only six worsening.

There was no change in testosterone levels, suggesting no hormone interference.

prostatewarriors.com/2025/0...

[KocoPr]

That is amazing! There is our random controlled trial to prove that some supplements and pre/probiotics work.

[KocoPr]

do they publicize the exact formula?

I can’t seem to find the trial number or name.

[KocoPr in reply to KocoPr]

Here is the link.

isrctn.com/ISRCTN81939514?u...

The clinical trial you’re referring to, which investigated the effects of a phytochemical-rich food supplement with or without a probiotic/prebiotic blend on prostate cancer progression, is registered under the identifier ISRCTN81939514. This trial, titled “Indolent prostate cancer, phytochemicals and probiotics,” is listed in the ISRCTN registry.

As of now, this specific study does not have a corresponding NCT number in the ClinicalTrials.gov database. The ISRCTN (International Standard Randomised Controlled Trial Number) registry is a primary clinical trial registry recognized by the World Health Organization, similar to ClinicalTrials.gov, but operates independently.

For more detailed information about the trial, including its design and objectives, you can visit the ISRCTN registry entry.

[Broccoli24]

This is amazingly encouraging news in what has been a fairly bumpy week… thank God someone is doing these tests! Very encouraging… though I suppose these guys didn’t have metastatic PC… or did they?

Do you have a link to the original source?

[Maxone73 in reply to Broccoli24]

Koko replied about the original study link. I am reading through the proceedings of ASCO 2025, so my source is a pdf file at the moment. But you are right, its for localized wait and see prostate cancer. But the point is: there is a relationship between prostate cancer "communication" axis and dietary products. 😀😀

[Broccoli24 in reply to Maxone73]

Thanks, that’s really positive, despite indolent profile… anything we can do to tilt the scale in our favour is worth doing in my book. And I wonder how these supplements compare with a ground up dietary regime change, which is what several of us are doing.

Looking forward to more news from ASCO!

[KocoPr]

ChatGPT:

The full study protocol for the trial titled “Indolent prostate cancer, phytochemicals and probiotics” (ISRCTN81939514) is not publicly available through the ISRCTN registry. To obtain detailed information, including specific dosages of the supplements used, you can contact the research team directly. The ISRCTN registry suggests reaching out to the study’s sponsor or principal investigator for such inquiries. Their contact information is typically provided in the study’s registry entry. If it’s not listed, you might consider contacting the institution overseeing the research for further assistance.

[Maxone73 in reply to KocoPr]

The study is from a public UK hospital if I remember correctly, I think they will have no problem disclosing the "recipe"

[Broccoli24 in reply to Maxone73]

Bedford Hospital I think.

[KocoPr in reply to Broccoli24]

Correct.

Bedford and Addenbrookes Cambridge University Hospital NHS

Here is the trial

isrctn.com/ISRCTN81939514?u...

[KocoPr in reply to Maxone73]

I emailed the lead investigator yesterday

[Mrtroxely]

Interesting.But also absolutely nothing to loose in trying and trialing!

More smoke which is pointing towards.

Something entering, igniting and fueling cancers...

Food, water, air, environment...

Your 52 as well, probly like me wondering why did I get it so young???

I don't feel like mother nature wants me off the planet just yet?

I'm a good, dad, partner, friend, I'm useful to the planet still...

[Maxone73 in reply to Mrtroxely]

We must resist!

[Cooolone]

The biggest problem I see is the replication of the trial for personal use. Supplement companies will take advantage and push a product etc., but obtaining lab certified ingredients and content is always the problem, aside from identifying specific content used by the study. Fancy labeling and lots of gobbly goop on websites selling snake oil by these companies is problematic, buyer beware, lol.

I went through this trying to identify and source Genistein...

In my initial diagnosis stage prior to first line therapy (RP) and afterwards I have had consults with an Alternative Medicine Oncologist @ MSKCC. Very informative, educational and eye opener. It most certainly assisted me kicking of my journey.

What I mean to say in the above paragraph is MY Broccoli isn't necessarily YOUR Broccoli, lol. I do take supplements, for anti-inflammatory effect and immune modulation. I seek out the best I can get, and price comes second. But the supplements are also secondary to diet. I try, but no way could I go Vegan or even strict Mediterranean... I love my Steak, lol. But it's maybe a few times per year kinda thing.

Maybe there's a reason why my wife had Covid 2x and I didn't... Especially through chemo and a weakened state. Anyways...

I absolutely agree that the metabolic side of things do not get accounted for... And it's outside the wheelhouse of most Oncologists unless they've spent the extra time to train in the discipline.

Hope this spurs additional interest and more controlled studies to support the hypothesis! Mainly to our benefit!!!

Thanks for posting!

[dhccpa]

Careful, Stranger. We don't harkin to no gunslingers coming to town and pushing their healthy diet ideas. Next thing it'll be DMSO, baking soda and molasses. Take them supplements back East and pee em in the river.

[Maxone73 in reply to dhccpa]

😂😂