Methionine Restriction

[cigafred]

I would have thought methionine was both too ubiquitous and too important for its restriction to be a valid PCa treatment.

"During the time the patient was on methionine restriction alone, effected by a low-methionine diet and o-rMETase, the metastatic prostate cancer did not progress. "

urotoday.com/recent-abstrac...

[cigafred]

I received this direct reply from our most erudite, but alas banned, friend:

"If methionine was ubiquitous, we would not need the SAM cycle to recycle homocysteine back to methionine by adding methyl.

Restriction can be achieved by restricting methyl donor intake - particularly folate or folic acid. This is difficult in the US, because grains are fortified with folic acid (this includes rice, but not the more obscure grains - read the label before buying.) Alternatively (my approach), restrict B12 intake. It is an essential cofactor in the SAM cycle."

I agree and am keeping my B12 levels low.

[MateoBeach in reply to cigafred]

Yes, methionine and folic acid are necessary to Cell cycle Replication including cancer cell proliferation as well as healing and blood cell Replacement. Not specific To cancer. We can’t be healthy without Maintaining blood cell lines etc. so dietary restriction seems a fool’s errand. I take methylated folic acid and B12 supplement 4 days per week. MB

[kainasar in reply to MateoBeach]

Ive read here and elsewhere that B12 and Folic related arent good. Ive tried low methionine foods, and recently have one B12 and one iron supp a week with K.

If I get tired , or out of breath , I will have higher level foods, such as beans tofu and oatmeal.

[Lizzo30]

Hydrogen peroxide alters methionine

People with schizophrenia have high methionine

Furthermore African American men have higher levels of methionine - and are more likely to get prostate cancer

[Eieio]

this would not actually be considered to study with an N=1 a 66 year-old patient who had both surgery, proton and immunotherapy. I wouldn’t hold a lot of validity to this.. I know from my own experience I stopped homocystine for high blood pressure when I realized it pooled excessive methionine. concurrent with reoccurrence and PSA elevation. Unfortunately creating one met and onset of castrate resistance.