New Car-T therapy announces initial results, how exercise helps in the fight against cancer, FDA approves EZRA AI for faster PC diagnosis

[NPfisherman]

Hello FPC folks,

Mustang Bio announces some initial and fairly substantial data involving their Car-T PSCA positive drug candidate MB-105. Impressive initial results from a patient this was administered to in the trial... In a 73-year-old male patient with PSCA-positive mCRPC who was treated with MB-105 and lymphodepletion (a standard CAR T pre-conditioning regimen) after failing eight prior therapies, MB-105 demonstrated on day 28 a 94 percent reduction in prostate-specific antigen (PSA), near complete reduction of measurable soft tissue metastasis by computerized tomography, and improvement in bone metastases by magnetic resonance imaging The trial is enrolling 33 candidates for Car-T treatment with MB-105 for MCRPC.

globenewswire.com/news-rele...

The clinical trial is STILL RECRUITING--out of City of Hope....some info:

clinicaltrials.gov/ct2/show...

Next, we learn that exercise helps to fight cancer through changing the metabolism of cytotoxic T cells-see below:

sciencedaily.com/releases/2...

Lastly, The FDA approval of Ezra AI for MRI making diagnosis faster and cheaper...

prnewswire.com/news-release...

The Science is Coming !!! and it gives us....HOPE !!!

Don Pescado

[Hope59]

Thank you!

[NPfisherman in reply to Hope59]

You are most welcome, Hope59...

Fish

[tom67inMA]

My MO said something that I later realized was a joke: "Try to be the first patient in a new study, because they always get a great response". Apparently he was referring to a trial where the first patient did very well, and the next 200+ didn't get any response.

I've been preaching exercise since diagnosis, but sadly my 30-ish miles of running every week in the fall of 2019 didn't stop a giant neuroendocrine tumor from forming in my bladder. But, I'm still here because I was healthy enough to endure chemo, and somebody else with a story remarkably similar to mine wasn't healthy enough and died this past spring.

Okay, while I'm bragging about exercise, I had 6 cycles of Carboplatin+Etoposide in the first half of 2020, and just started cabazitaxel two weeks ago. My latest blood test showed Hemoglobin at 12.1, platelets slightly low (120-something?), and neutrophils at 6.9(!). Apparently Neulasta worked very well for me.

But enough about that, it's time for me to head out and see how quickly I can cover 4 miles today

[NPfisherman in reply to tom67inMA]

Hi Tom,

Well, let's hope this CAR-T therapy has a better record than the one described by your MD...Keep exercising and Keep fighting....I do believe that these types of therapy hold real promise for the future... using your own immune cells to attack beats poison and burn IMHO...

Fish

[GreenStreet in reply to NPfisherman]

Thanks for the post. I believe exercise helps. I think I read somewhere that it can enhance the impact of radiotherapy if done immediately before radiotherapy because the greater oxygen in cells had an impact. I exercised each day before my SRT but it did not help because they were aiming in the wrong place. Lol. I also think it helps mitigate some of the impact of ADT. Tom I am sure your exercise helped you get through your treatment.

[NPfisherman in reply to GreenStreet]

I do some exercise daily, but during CoVid, I have let the gym go....I may go back soon...gained some weight and it needs to come off....

Fish

[tom67inMA in reply to NPfisherman]

I agree immunotherapy holds promise, but it can still have significant side effects. A friend was on atezolizumab and his thyroid gland was killed, no he's on hormone replacement for that for the rest of his life.

It doesn't matter whether it's chemical, radiation, or an immune cell, it all comes down to how well you can differentiate cancer from healthy cells. I'm going to try fasting prior to my next chemo, on the theory that a calorie shortage will cause healthy cells to become less active and less affected by chemo, while the cancer cells ignore such signals and remain vulnerable.

[NPfisherman in reply to tom67inMA]

Good plan....also consider exercise afterwards with the idea that extra oxygenation may help the chemo as well as circulating it around to kill cancer cells....Dayatatime used a stepper while doing chemo....

Fish

[tom67inMA in reply to NPfisherman]

I definitely try to exercise afterwards, as my condition (including benadryl grogginess) and the weather allows. Three weeks ago I jogged from the oncologist's office to the car. Today I'll have a bit of fun and ask if they can install a treadmill or stationary bike as an alternative to the recliners in the infusion room

Today is another infusion. I've had partial success so far in my attempt to fast prior to treatment. I had a bagel last night, but that's the only food I've had since breakfast yesterday, and I'm going to try to make it until at least late evening today. I'm about to go for a short walk before leaving the house, and will do another walk when I get back home. Perhaps I'll take a short walk on the hospital grounds immediately after the infusion, because it's at least an hour car ride home.

[NPfisherman in reply to tom67inMA]

Great ideas....Good luck...a stationary bike....nice thinking....May it have great success for you....

Fish

[tom67inMA in reply to NPfisherman]

My wife suggested that thing they're selling on TV which you can pedal while sitting on the couch watching TV. But of course, once the IV bendryl in the pre-treat hits me, all I can do is put on my headphones and go into the twilight zone for an hour or so. Oddly, "Twilight Zone" by Golden Earring came up on shuffle play recently.

[NPfisherman in reply to tom67inMA]

I'm sure if you asked for the stationary bike they might give it...can't see why not... Best of luck....

Fish