Preclinical: rifaximin, repurposing that might work

[Maxone73]

Repurposing existing drugs, such as rifaximin, can accelerate the development of new treatments because their safety profiles are already established. A recent study screened 3,800 FDA-approved drugs and identified rifaximin as a promising lead compound for PIM-1 inhibition.

The potential of rifaximin lies in its ability to disrupt PIM-1, potentially slowing or halting the progression of prostate cancer, especially in hormone-resistant cases. The established safety profile of rifaximin could simplify its transition into clinical trials, potentially broadening prostate cancer treatment strategies.

prostatewarriors.com/2024/1...

[swwags]

Source? There's no source mentioned. No planned clinical trials noted.

[Maxone73 in reply to swwags]

Source isnat the end of the article, and no, it's a preclinical research, probably not ready for clinical trial.

[dhccpa]

I've been hearing about repurposing for years. And yet...

I know some have occurred. But any at all for cancer treatment? And specifically prostate cancer?

[Maxone73 in reply to dhccpa]

From memory I would say aspirin for colorectal cancer and thalidomide for multiple myeloma. There will be more examples with all the new technologies but their testing will always be slower....it. an only be publicly funded. I have been considering the idea of creating a charity with prostatewarriors.com and choose a "cheap" project to finance....must be repurposing or some phase 1 at university level, I am not that famous yet! 😄😄 but I would focus on only one research at a time.

[dhccpa in reply to Maxone73]

Was Viagra a repurposed drug?

Metformin and atorvastatin have been used for years by cancer patients and by Care Oncology Clinic, but I don't see much movement in that direction.

[Maxone73 in reply to dhccpa]

Yes it was repurposed, propecia too. Clinical trials, except for STAMPEDE and only for high burden metastatic PCa, showed no survival benefit from metformin, but it's still useful to fight metabolic syndrome. If I am not wrong in colorectal patients metformin was proven beneficial but only as chemo-prevention and in early stage disease. Personally if I do not see a threat to SOC (providing that SOC is working) I see no harm in trying these alternatives.

[dhccpa in reply to Maxone73]

Agreed