Kaempferol, a key active ingredient in the traditional Chinese medicine formula Chaihu-Shugan-San (CSS), shows promise in treating emotional stress-aggravated prostate cancer metastasis.
Actually I did not even know that there were stress-aggravated cancer metastasis...but I suppose that stress is a darn bad thing always!
Kaempferol enhances the secretion of α2M, a protease inhibitor that suppresses tumor cell invasion and metastasis. It also inhibits prostate cancer cell migration and the GR/PER1 pathway, which is activated by stress-induced glucocorticoids and leads to enhanced lipid metabolism in TAMs.
By targeting the GR/PER1 pathway and modulating lipid metabolism in TAMs, kaempferol may offer a new therapeutic strategy for managing prostate cancer metastasis, particularly in patients experiencing emotional stress. Further research is necessary to fully understand its mechanisms of action and evaluate its clinical efficacy and safety.
Note: kaempferol is present in many vegetables and teas that we eat daily.
I have a stressful situation now brought on my famous Boston Hospital. I’m on combination of Chemo and Immunotherapy, and want 60% Chemo, instead of 100%, which can be a thing, but they buck me every step of the way
They need to find an old copy of Hippocratic Oath, and FIRST DO NO HARM.
My next infusions start Monday, and yet they wouldn’t agree to 60% when I requested yesterday
So now me and my family live with STRESS during this long Thanksgiving holiday
Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans, Nutrients, 2019 Sep 25; 11(10):2288:
Abstract
Fruit and vegetable intake has been associated with a reduced risk of cardiovascular disease. Quercetin and kaempferol are among the most ubiquitous polyphenols in fruit and vegetables. Most of the quercetin and kaempferol in plants is attached to sugar moieties rather than in the free form. The types and attachments of sugars impact bioavailability, and thus bioactivity. This article aims to review the current literature on the bioavailability of quercetin and kaempferol from food sources and evaluate the potential cardiovascular effects in humans. Foods with the highest concentrations of quercetin and kaempferol in plants are not necessarily the most bioavailable sources. Glucoside conjugates which are found in onions appear to have the highest bioavailability in humans. The absorbed quercetin and kaempferol are rapidly metabolized in the liver and circulate as methyl, glucuronide, and sulfate metabolites. These metabolites can be measured in the blood and urine to assess bioactivity in human trials. The optimal effective dose of quercetin reported to have beneficial effect of lowering blood pressure and inflammation is 500 mg of the aglycone form. Few clinical studies have examined the potential cardiovascular effects of high intakes of quercetin- and kaempferol-rich plants. However, it is possible that a lower dosage from plant sources could be effective due to of its higher bioavailability compared to the aglycone form. Studies are needed to evaluate the potential cardiovascular benefits of plants rich in quercetin and kaempferol glycoside conjugates.
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