Phase 1 recruiting: QXL138AM, for CD138 expressing tumors

[Maxone73]

Another one I almost missed...

CD138 is expressed in advanced and aggressive prostate cancers, playing a role in tumor progression and interactions with the microenvironment. Its expression is higher in metastatic disease, making it a potential biomarker for aggressiveness.

QXL138AM is a masked immuno-cytokine (MIC) targeting CD138, a receptor found in prostate cancer and other CD138-expressing tumors. It delivers interferon alpha 2 (IFNα2) directly to the tumor site, enhancing anti-tumor activity while minimizing systemic toxicity through a tumor-selective masking mechanism.

Preclinical studies showed 69% tumor growth inhibition in prostate cancer models, highlighting its potential. QXL138AM has also received FDA Orphan Drug Designation for multiple myeloma and pancreatic cancer.

Currently in Phase 1 clinical trials (NCT06582017) and recruiting participants, the study is assessing its safety, dosing, and early efficacy in patients with CD138-positive cancers, including prostate cancer. This innovative therapy represents a promising option for patients with advanced, hard-to-treat cancers.

prostatewarriors.com/2024/1...

[MoonRocket]

I wonder how prevalent this mutation is in prostate cancer.

[Maxone73 in reply to MoonRocket]

Considering all stages, around 20%, but from what I read the percentage is higher in aggressive prostate cancer.

[MoonRocket in reply to Maxone73]

I posted about my chatgpt exercise on my previous genetic testing. I'm interested to see what shows up on this most recent bone biopsy.I expect to see the same set but wondering if others will show opening the door to possible additional treatments.

[Maxone73 in reply to MoonRocket]

Genetic panel also of metastasis is so important! Surprised that it's not a standard everywhere!

[MoonRocket in reply to Maxone73]

They do the cheap germline testing but that doesn't cover the somatic which is where I tested positive. So now, based on interviews and panel discussions by leading researchers I'm getting updated genetic testing done to see if additional actionable mutations are detected.

[Maxone73 in reply to MoonRocket]

I hope you will be super lucky!

[MoonRocket in reply to Maxone73]

Lucky for me right now is to finish up this SBRT to met on the Ischial Tuberosity and then be able to take a vacation for an extended period of time. My MO discussed adding Lynparza and I brought up Talenza. I might even look into that new PARP inhibitor via a clinical trial but maybe the twarted since I haven't had chemo yet. But first things first.

[Maxone73 in reply to MoonRocket]

Complete vacation or stixking to ADT?

[MoonRocket in reply to Maxone73]

Complete vacation. 🫰

[Maxone73 in reply to MoonRocket]

🤞🤞🤞