Preclinical: A new way to starve cancer

[Maxone73]

Nothing to do with diet, at least I do not think so, but two promising new targets to test.

Researchers at Indiana University School of Medicine have identified a new way to target prostate cancer by depriving tumors of amino acids. The team found that when nutrients are depleted, a protein called GCN2 signals cells to make more fuel for growth. While inhibiting GCN2 slowed tumor growth, it didn't kill the cancer, which activated a backup plan.

The protein p53, which is retained in most prostate cancers, signals to restrict cell division and gather nutrients. The researchers discovered that inhibiting both GCN2 and p53 effectively destroyed prostate cancer cells. This approach exploits metabolic vulnerabilities unique to prostate cancer. The study was published in Science Signaling.

In my opinion the concept here is that (at least in mice) P53 deficient tumors (quite common mutation in prostate cancer) can effectively be targeted by GCN2 inhibition.

prostatewarriors.com/2024/1...

[Broccoli24]

This seems very exciting... now how easy is it to inhibit GNC2 & P53 I wonder... and will it have side effects? Something like the could be a much less invasive treatment for us. Wishing them Godspeed!

[Maxone73 in reply to Broccoli24]

let's hope to ge as reactive as mice!

I don't know about their side effects, but inhibition of both p53 and GNC2 is what they did to test their theory.