I believe my amigo Nalakrats has stressed the importance of this and may weigh in on this one... Ohio State University researchers show how Thrombin, a clotting protein causes blood platelets to release TGF-b1which is known to cause progression in prostate cancer and suppress immune system responses to cancer...
Key findings include:
•Thrombin cleaves a molecule called GARP (glycoprotein A repetitions predominant) that is found on the surface of platelets;
•GARP cleavage leads to the release of mature TGF-1b from platelets;
•This cleavage is required to activate platelet TGF-b1;
•Blocking thrombin using the inhibitor dabigatran etexilate greatly altered the tumor microenvironment and increased the number and activity of tumor-infiltrating T cells, natural killer cells and neutrophils.
The Science is Coming !!! Come on....SCIENCE !!!!