A new study reveals how a clotting protein and blood platelets can promote cancer progression and suppress immune responses to cancer

[NPfisherman]

I believe my amigo Nalakrats has stressed the importance of this and may weigh in on this one... Ohio State University researchers show how Thrombin, a clotting protein causes blood platelets to release TGF-b1which is known to cause progression in prostate cancer and suppress immune system responses to cancer...

sciencedaily.com/releases/2...

Key findings include:

•Thrombin cleaves a molecule called GARP (glycoprotein A repetitions predominant) that is found on the surface of platelets;

•GARP cleavage leads to the release of mature TGF-1b from platelets;

•This cleavage is required to activate platelet TGF-b1;

•Blocking thrombin using the inhibitor dabigatran etexilate greatly altered the tumor microenvironment and increased the number and activity of tumor-infiltrating T cells, natural killer cells and neutrophils.

The Science is Coming !!! Come on....SCIENCE !!!!

Don Pescado

[cujoe]

Key findings include:

• Thrombin cleaves a molecule called GARP (glycoprotein A repetitions predominant) that is found on the surface of platelets;

• GARP cleavage leads to the release of mature TGF-1b from platelets;

• This cleavage is required to activate platelet TGF-b1;

• Blocking thrombin using the inhibitor dabigatran etexilate * (see PS below) greatly altered the tumor microenvironment and increased the number and activity of tumor-infiltrating T cells, natural killer cells and neutrophils.

"Overall, our study reveals a mechanism of cancer immune evasion that involves thrombin-mediated GARP cleavage and the release of TGF-b1 by platelets," Li says. "It also suggests that blocking GARP cleavage could be an effective therapeutic strategy for overcoming cancer's resistance to immunotherapy."

A case of The Cancer World According To GARP.

As always, Thanks for the Science, Fish.

Be Well & Don't Get Stressed Out Today - Captain K9

]

PS here's the scoop on Dabigatran Etexilate from Drugs.com.

drugs.com/ppa/dabigatran-et...

and a link to Wiki page on Thrombin

en.wikipedia.org/wiki/Thrombin

[NPfisherman in reply to cujoe]

With Pradaxa already on the market, I am surprised that they are not trying some of the immunotherapy trials with Pradaxa to get more "bang for the buck" ...it is something to keep in mind for things like APCEDEN or other vaccines...Thanks for the reply...

My Stress was NEGATIVE.... no cardiac cath for this Fish...

Q Fish

[cujoe in reply to NPfisherman]

Go fishing, you stress-free science sleuth!

[NPfisherman in reply to cujoe]

K9 Captain,

I may have to go get an early license as it has been reasonably warm for winter...50's-60's....if the rain would just let the water clear for a few days....

Fish

[NPfisherman]

It is why I take Dr.'s Best NattoSerra daily... Trying to cover as many angles as possible... Had a single vessel CABG in 2012-- Recent t Stress test result--Negative and hoping to keep it that way...

Thanks for the reply...

Fish

[teamkv in reply to NPfisherman]

What amount and when do you dose? My husband is taking 3 per day, on an empty stomach in the morning I think.

[NPfisherman in reply to teamkv]

If you are referring to the Dr's Best Nattoserra then I take it daily-- at night and Aspirin 2x a day...the person to ask more on this issue would be Nalakrats as he is the best read on supplements.... The label states no established daily doseage...Hope this helps...

Fish

[teamkv in reply to NPfisherman]

How much do you take?

[NPfisherman in reply to teamkv]

I take once daily--at night--with aspirin.... cujoe also takes this one and you may wish to ask him what he does, and Nalakrats as well...

Fish

[NPfisherman]

Nal,

It was the LAD--left anterior descending and it was 99% occluded in 1 area, 90% in another, and 85% in a 3rd...I did NOT have an MI by the grace and mercy of God...On a Friday afternoon, after my cardiac catheterization, they said..."We would put you on the operating table right now, but we do not have staff now...On Monday morning, you will have open heart surgery.. Don't do anything strenuous--sit at home..."-- and I did.... LIMA bypass graft... Quite the story... God is not done with me here yet...

Fish

[NPfisherman]

You--Dead and Me--Near Dead with a fatal MI---they call the LAD MI's--"The Widowmaker" as people routinely fall into fatal arrhythmias when they occur...

As I frequently tell people, I have evaded Death a number of times including a car crash where the rear end of my car was driven up to the back of my driver's seat and I was hit by multiple vehicles, including the finale of a Cadillac Escalade smashing into the driver's door knocking me unconscious... I awoke to the gentle call of ,"Hey Buddy, Are you ok?? " and crawled across the front seat to the passenger door slowly as fuel leaked out on the road all around the vehicle...

I guess we are here for a reason, Nal....

Fish

[TFBUNDY in reply to NPfisherman]

Bloody hell Don. You lead a much more exciting life than me. No wonder you want to hang on... Cheers

[NPfisherman in reply to TFBUNDY]

LOL... It's been an interesting life that is for sure... I scuba dive, ski, and of course, enjoy fishing... Just another dude trying to hang on for a while.... Keep things going in the UK, TFBUNDY... maybe I'll make it there and we'll hoist a pint at the local pub...

Fish

[TFBUNDY in reply to NPfisherman]

Did a bit of SCUBA in the Red Sea, but little scope for it in London. Glad to see you for a pint if you very make it across the pond, but remember they never come in ones. And remind me not to let you touch my car. Cheers

[NPfisherman in reply to TFBUNDY]

More than one sounds good...As for the car....can't blame you there..... That was some crazy wreck... here's the finale on that story, my Ex-wife, when I called afterwards and said I needed a lift, told me, "Can't you make it home on your own??"... You can see why she is the EX.... what a treasure she was...

Fish

[TFBUNDY in reply to NPfisherman]

Ex wives never understand. Seems to go with the territory. What's up with 'em? Cheers

[NPfisherman in reply to TFBUNDY]

Mine tries to be empathetic with finding out my diagnosis, but there is too much water under the bridge to even get to a friend position despite the kids...

Fish

[NPfisherman]

My head is like a sieve on ADT.....ideas come and go.... actually, I found Taurine is helping that quite a bit... You are a Taurine fan as well I believe... I do know what my purpose is and why I am here....there are numerous reasons and things to accomplish ...

I monitor what goes on at APC, despite not participating.... In the meantime, I continue to work and do the research and bring the science... as I say...

The Science is Coming...and it gives us....HOPE !!!!

Fish

[cujoe in reply to NPfisherman]

Well, That explains a lot about both of you. I was alway suspicious we had some super smart zombies among us. BTW, Nalakrats, Natto-Serra is one of my mainstay supplements I owe to you. Information>Understanding>Knowledge>Truth.

Enjoy that FLA sunshine & Be Well - K9

[NPfisherman in reply to cujoe]

A Zombie Fish....isn't that like a snakehead?? I am a horrible, bad dude...just ask Mr. D... LOL .. the truth is just painful sometimes for some people...

Z-Fish

[cujoe in reply to NPfisherman]

Never heard of snakeheads and had to look them up:

Freezing snakeheads is a way to assure they’re dead -- sort of like shooting zombies in the head. They are voracious eaters of other fish, birds and mammals, and have an otherworldly ability to survive on land for up to four days, experts say.

charlotteobserver.com/news/...

[NPfisherman in reply to cujoe]

An evolutionary nightmare....physically and literally.... causing havoc wherever they go... one bad hombre...

Fish

[ProstateWhisperer]

Dipyridamole reportedly inhibits TGF-beta.

[NPfisherman in reply to ProstateWhisperer]

Yes, and it has shown benefit when given with a statin....

sciencedirect.com/science/a...

Worth looking at doing....all IMHO....

Fish