As you know, we have an abundance of "stuff" that can kill cancer cells in a bucketload of ways (please note the scientific terms I used 
) but we need ways to target only cancer cells to make treatments a breeze on our body
sciencedirect.com/science/a...
Why is 4armPEG-DD a good candidate to help us?
● Targeted Delivery: 4armPEG-DD is designed to specifically target PSMA-positive prostate cancer cells. PSMA is overexpressed in 80-90% of prostate cancers, making it a suitable target for therapy. This targeted approach is expected to increase the drug's effectiveness while minimizing its impact on healthy cells.
● Enhanced Permeability and Retention (EPR) Effect: The nano-size of 4armPEG-DD (approximately 110 nm) allows it to take advantage of the EPR effect. This means that the nanoprodrug can preferentially accumulate in tumor tissues due to the leaky vasculature and impaired lymphatic drainage often found in tumors.
● Controlled Release: The disulfide bond linking docetaxel to the 4-arm PEG is sensitive to the reducing environment inside tumor cells. This ensures that docetaxel is released primarily within the cancer cells, reducing systemic toxicity.
● Biocompatibility: The use of PEG as the carrier material contributes to the safety of the nanoprodrug. PEG is biocompatible and has a long history of safe use in clinical settings. This reduces the risk of adverse reactions and improves the overall tolerability of the treatment.
The fact that it has a long history of use in clinical settings could also shorten the clinical trials!
