Metabolic syndrome is associated with aggressive prostate cancer

[pjoshea13]

New study from Steve Freedland [1].

I almost went to see him years ago when he was in Durham, NC. He moved to Cedars-Sinai in LA, but still these studies come out from Durham.

"Recent meta-analyses suggest the Metabolic Syndrome (MS) increases high-grade prostate cancer (PC), although studies are inconsistent and few black men were included. We investigated MS and PC diagnosis in black and white men undergoing prostate biopsy in an equal access healthcare system."

"Among men undergoing prostate biopsy at the Durham Veterans Affairs Hospital, medical record data abstraction of diagnosis or treatment for hypertension (≥ 130/85 mmHg), dyslipidemia (HDL < 40 mg/dL), hypertriglyceridemia (≥ 150 mg/dL), diabetes, hyperglycemia (fasting glucose ≥ 100 ml/dL), and central obesity (waist circumference ≥ 40 inches) were done."

"Of 1,051 men (57% black), 532 (51%) had MS. Men with MS were older, more likely to be non-black, and had a larger prostate volume ... On multivariable analysis, MS was associated with high-grade PC (OR = 1.73 ...), but not overall PC (OR = 1.17 ...) or low grade (OR = 0.87 ...). Results were similar in black and non-black men"

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/364...