Advice on increased stimulation meds - Fertility Network UK

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Advice on increased stimulation meds

CarlsAreUs profile image
17 Replies

Hello everyone. I just wanted to ask advise. I am due to start my second round of ivf in the next few months. In my first round I only had 4 eggs retrieved, 3 fertilised however unfortunately none made it to the blastocyst stage.

For my 2nd round the clinic have said I can increase the stimulation meds. They said this might not always increase the outcome however it can. I just wondered if anyone else has had any experience of this? Or any advice?

Thanks so much ☺️

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17 Replies
bundles11 profile image
bundles11

I had my dose increased for my second round and had a better retrieval. I think it's definitely worth trying.

CarlsAreUs profile image
CarlsAreUs in reply tobundles11

That’s great to hear. Thanks for your reply!

chocchoc12 profile image
chocchoc12

Yes, this happened to me. First round I got 8 mature eggs and 2 blastocysts. The doctor said I was a low responder for the level my AMH was so she increased my FSH dose from 150 to 200. The second round got 18 mature eggs and 5 blastocysts. I did 6 back to back rounds and all yielded different results when comparing how many days I stimmed for.

CarlsAreUs profile image
CarlsAreUs

Really? That’s great to hear. It’s mad how different it can be every time! Thanks for letting me know!

Samuk14 profile image
Samuk14

I’m currently going through increased meds and on day 2 of stuns.

- in my first round they upped my daily dose from 200-250 and retrieved five eggs.

This time round I’ve changed to menopur and having 300 daily so hopefully improvement in number or quality x

CarlsAreUs profile image
CarlsAreUs in reply toSamuk14

Wishing you all the luck for your 2nd round Samuk14 Hope you’re feeling ok with it all X

MiniCeeCee profile image
MiniCeeCee

hey @carlsareus, I’m in a similar position, starting stimulation next month and increasing from 150 Gonal F (got 9 eggs and 4 blasts but 3 were lower quality and sadly none of them have stuck), to 262 Gonal F. Hoping will get more eggs and better quality this time. I’ve got a niggle that I’m going to speak to my clinic about though around the quality and wherever it’s worth having a mix of recombinant (Gonal F) and urinary (ie menopur) as apparently mixing the two can sometimes help with quality, Samuk14 you mention switching to menopur for quality- can I ask what your clinic said about the switch? As I’m wondering whether to explore it. Thanks!

Crazycatlady007 profile image
Crazycatlady007 in reply toMiniCeeCee

Sorry to jump in but my clinic did this for me (rekovelle and meriofert) and my quality improved but quantity went down x

MiniCeeCee profile image
MiniCeeCee in reply toCrazycatlady007

Thanks for sharing Crazycatlady007 did they increase the dost of stims too? So hard to work through what’s the best option!

Bisquisite profile image
Bisquisite

First round I was on 350 Menopur - I think 6 eggs retrieved but none made it to blast.

Was told that first round is just to see how your body responds etc. Didn’t have any expectations really.

Second round increased to 450 Menopur (or whatever the maximum is). Ended up with some mild OHSS symptoms tho - collection results were better - a couple more eggs this time with two making it to blast - these were sent off for PGTA testing but sadly both aneuploid.

Third round - kept the same max dose - changed trigger to Buserelin to avoid OHSS symptoms - got 14 eggs - had 5 blasts to send for testing - 3 came back as okay. (Third round I had started taking CoQ10 and NAC and R-Alpha Lipoic Acid supplements for about 4-6 weeks)

I was about 39.5 years when this all took place.

CarlsAreUs profile image
CarlsAreUs in reply toBisquisite

Thanks so much for your message Bisquisite it really it mad how many different methods there are. Glad to hear that this has worked for other people. I’m so glad to hear about your third round and how successful it was! That’s great on the supplements as well, I’m taking these. My friend recommended the book and started taking these about a month ago. Throwing everything at it. Thanks again for your reply!

Crazycatlady007 profile image
Crazycatlady007

Helloo! I had my meds increased and used a mix to try and improve quality. It definitely improved quality but for me, the volume of eggs and mature ones decreased but I got more blasts! Feel like an actual science experiment! Good luck! xx

CarlsAreUs profile image
CarlsAreUs in reply toCrazycatlady007

Hi Crazycatlady007 thanks for your reply!! That’s great news to hear. Yeh it does seem like such an experiment doesn’t it. Although I can do with avoiding the less volume as I didn’t get alot the first time 🙈. Thanks so much! Xx

Figgypudding89 profile image
Figgypudding89

Just wanted to say thanks for asking this! I had my first egg retrieval yesterday and despite good diet and all the crazy work I put in I only got 5 eggs and was really sad about it. Reading these replies helps me to realise that it's pretty normal to do multiple rounds and that likely a change to my protocol should help increase chances. So thank you! ❤️ Xx

CarlsAreUs profile image
CarlsAreUs in reply toFiggypudding89

Hi Figgypudding89 I know how you’re feeling 100%!! Sending lots of hugs! It’s all such a shock isn’t it. And different to how you think it all happens. Please be kind to yourself as well, as I know I was so emotional where you have so many more hormones in your body! I was all over the place.

But 100% agree and even though some forums can be overwhelming you do learn that it’s quite normal and everyone’s reaction is so so different.

Everyone also says you only need one❤️ This can still work for you with 5 as well.

Good luck and be kind to yourself. Xx

Figgypudding89 profile image
Figgypudding89 in reply toCarlsAreUs

You are so kind, thank you so much for your sweet reply! Omg the hormones 😂 it has been a rollercoaster. You're spot on in being kind to myself, I've had to learn to do that more than ever during this process and still a work in progress but certainly getting better at it slowly (IVF has no shortage of opportunities to practice 😂). Best of luck to you too, we can do this! Xxx

CarlsAreUs profile image
CarlsAreUs in reply toFiggypudding89

Thank you ☺️

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