If only issue is low AMH, why haven’t we conceived!?

[Mlove12]

Got the results back from Sperm DNA frag and my uterine biopsy and NK cell result- all fine! No issues. (See profile for past round updates/circumstances)

I dont know where to go from here. We dont have embryos to test so can’t do the pgta testing.

Feeling frustrated going into another round with only an extra trigger and some extra medication (regarding insulin, my uterine biopsy was borderline for this but kindly said they would prescribe after some convincing!). Just feels it could be thousands of pounds wasted to have nothing by the end of it…. Don’t know where to go from here.

Hope your all well! X

[Marisa32]

So sorry to hear. Unexplained fertility issue is the worst. Have you had the karotype/genetic test on you or your partner done? Low AMH should not be an issue when ttc naturally, as you get that one egg per cycle regardless. Depending on age, it may take many cycles to find a good one.

[Mlove12 in reply to Marisa32]

Hi Marisa,

We haven’t had any genetic testing done. Is this something you recommend? We’ve never had a positive pregnancy test so wondered if it was genetic abnormalities whether this would still implant but then miscarry which is not something we have experienced? We have our next consultation next month so any suggestions welcome 😀

[Marisa32 in reply to Mlove12]

Yes, I would definitely recommend it. It's one of the tests done routinely prior to IVF in some countries in EU and in the US. It identified that my brother was a carrier of a chromosomal translocation making natural pregnancy nearly impossible. It may or may not turn up anything but at least you know that genetics was looked at.

[pink_lemon]

hello Mlove, I am sorry you are going through this and cannot find answers. You are very young (28, right?) so pgt testing should not be what would do the trick at your age. I was going to suggest having your tubes flushed (hycosy if I remember correctly). That might help with trying naturally. Then I had a look that in your second cycle no eggs (out of 8!) fertilised. Generally about 50% eggs should be expected to fertilise. Of course it is not always the case but for two young healthy people, I would probably be looking into that as well? Maybe change of clinic? Why did your clinic say this could have happened? Somethung I would be trying to find an answer for. Hope others will have some useful suggestions for you too.

[Mlove12 in reply to pink_lemon]

Hey,

Yes that’s correct I had my tubes checked with NHS in 2021 prior to being referred for IVF, is this the same thing as having them flushed as they put fluid through my tubes to check they were not blocked?

We aren’t sure what else to do in terms of fertilisation, they said that 4 of my eggs were immature so wouldn’t fertilise and one was degenerate so was useless and 3 were mature but didn’t fertilise/fertilised abnormally. Prior to this the 3 mature eggs did fertilise hence why I think my clinic are not too worried about this. They didn’t suggest anything but did encourage us to continue with my own eggs, i just worry they are not going to work at this point, thought it may have been implantation issue but after the biopsy they’ve said no reason for concern in terms of implantation- sigh! We have a consultation with a different consultant this time so hopefully a fresh pair of eyes will help! X

[pink_lemon in reply to Mlove12]

yes, flushing tubes is what I meant. Hope your new consultant will have some ideas. I just personally feel low AMH at your age should not be a great barrier. Really hope you are lucky the third time around or else manage to get to the bottom of things. xx

[Skittles11]

Hi Mlove. You've mentioned insulin in this post and some extra medication, was it to do with being insulin resistant? Thanks lovely xx

[Mlove12 in reply to Skittles11]

Hi Skittles, so im being prescribed sitagliptin, which is what they use predominantly for people with type 2 diabetes and don’t make enough insulin. This was due to my uterine biopsy results and not any kind of diabetes test. It’s not been tested throughly in regards to its effects on implantation/fertility treatment.

I’m not actually diabetic (as far as I know!) but Dr Brosens mentioned something to do with the way my lining grows, if im honest, I can’t really remember what he said! But something do to with ‘its slightly off kilter but borderline’ so he didn’t want to prescribe the meds, but with some convincing as this is our last round he said he would. It’s meant to support with the direction the lining grows. Sorry I dont have any more info! Hope your well xx

[Skittles11 in reply to Mlove12]

Thanks lovely x