Will IVF ever work for a 36 yo woman with endometriosis after 6 Failed transfers already? Any similar / Success stories?

[BetsyBo]

Hi,

I’ve not been on here for a while. Following another failed transfer I’m back to that place of feeing pretty hopeless. I looked on my feed and saw I requested something similar a while back but I’m after more specific success stories now as they aren’t helping me right now. So…

Does IVF ever work for people with endo/recurrent implantation failure?

And will it work after 6+ transfers?

Grasping at straws but just need to hear some more positive stories .

Thanks in advance x

[Lovemylion]

Millbanks had success on 6th or 7th transfer I think. She did a few things differently for last cycle. Might be worth a chat with her.

Wishing you lots of luck 🍀 xx

[BetsyBo in reply to Lovemylion]

Thanks for letting me know lovely 😊

[Millbanks in reply to BetsyBo]

Thanks Lovemylion ❤️

Hi Betsy- yep I had 4 egg collections and 6 transfers, my Fallopian tubes clipped, a polyp removed, a HSG exam, an ERA test, immune testing and PGS testing - finally it worked.

If you’d like to chat feel free to pm me xxx

[BetsyBo in reply to Millbanks]

Thank you so much and congratulations on getting there finally!!xxx

[Hidden]

My friend had her two children on her 7th and 8th transfers with her last two (worst quality) embryos - she had terrible endo with blocked tubes and had never had a BFP previously. She did nothing different.

Another friend had her first BFP on transfer number 9 and then got pregnant naturally 12 months later - again never having had anything but BFNs before

Good luck x

[BetsyBo]

Oh my goodness this is the kind of stuff I need to hear to keep my hope alive! Thank you so so much for sharing xxx

[Aussie83]

I am 4 months pregnant now after using our two lowest quality embryos and it was our 6th transfer, after literally zilch on tests through 2 years of IVF. I was feeling the exact same way as you 6 months ago but please know it does happen x

[BetsyBo in reply to Aussie83]

Thanks so much for sharing and massive congratulations xxx

[Seren0119]

Four years of IVF….five egg collections, and it finally happened. Please don’t give up x

[BetsyBo in reply to Seren0119]

5 egg collections - wow!! You’re amazing - thanks for sharing your story and congratulations xxx

[Mai94]

Endo treated 2 years ago, 3 rounds of ivf, two miscarriages one natural conception one ivf and a failed transfer. Almost 30 weeks pregnant with twins now!Differences this time was a double transfer, endometrial scratch, progesterone support in a natural fet, asprin and fragmin injections once I’d gotten the bfp.

Don’t give up lovely it happens!

A friend was given a next to nothing chance of a natural conception as her tubes were so damaged from endo. She had her son last year through ivf and has recently found out that she is pregnant naturally - 9 weeks now and totally unexpected!

Good luck 🤞🏽 x

[BetsyBo in reply to Mai94]

Ahh these are amazing stories and just what I need to hear! Thanks so much lovely xxx

[Jana483]

6 transfers and how many fresh cycles?

[BetsyBo in reply to Jana483]

We’ve just had one fresh cycle but didn’t make it to test day that time. Think we will be doing freeze all next time for PGS testing too and possibly ERA test xxx

[Jana483 in reply to BetsyBo]

This is honestly great news!You need at least 3 to 4 fresh cycles minimum to get a baby and sometimes even 6 fresh cycles!

(people for whom it works on the first go is blessed really)

So if you stim then they collect the eggs and then fertilize 6 embryos and you do 6 transfers its only considered one try!!!

Sometimes embryos from the same cycle are just not good enough to implant even if they grade them best quality.

I had 2 fresh cycles with total of 8 embryos transferd to get my daughter (all 3rd day transfers)

Second time also 2fresh cycles with total 4 transfers (total 9 embryos) to get my current pregnancy (all my embryos looks good on 3rd day but no idea why they don't plant)

So please don't lose hope I know it's hard I really know how you feel (had 3 cycles canceled as well) I thought about changing protocol doing extra tests but my doctor told me it's about the embryo and that sometimes 1 out of 12 embryos is the one!

I remember once I transfered 3 excellent Embryos and when I got the bfn I thought how could this happen what's wrong with my body.

And then I transfered another 3 Embryos that looked excellent as well and only one took currently 20 weeks pregnant, point is what about the other 2 from the same patch same quality why didn't they implant?

No body knows why some embryos implant and some don't but you need to try more if you can financially and emotionally it's worth it.

You don't want to think in the future why didn't I try harder.

I wish you the best of luck

😍

[Booda21]

This is literally me! I’ve had 6 transfers with 7 embryos, one very short lived bfp and not a sniff any other time. I’m just about to start my second round with egg collection. Going to do pgt-a testing this time. I have to do a freeze all too as I had an era and my progesterone levels can’t do a fresh. Im hoping and praying that I get a positive this time. But not holding my breath. I have only recently found out I have endometriosis as I have developed an endometrioma on each ovary and was told this could limit my ovarian response this time, just always there for the positive news aren’t they haha.

Wishing you all the luck in the world and hopefully we will be one of these positive stories to tell people and give hope one day!xxxx

[BetsyBo in reply to Booda21]

I have been thinking about the PHS testing but the costs with that on top of ERA test and all meds is just phenomenal- chatting to Dr in a bit so will see what he says as I do trust his judgement (I know that may sound stupid but he’s a nee Dr and for the last cycle we did something a bit different every time which absolutely did not happen with my NHS dr). I only found out I had endo the same way so had lap surgery and found I was riddled so that was all taken away in the hope it would help…hasn’t yet though. And didn’t have overly positive effect on stimulation either so I’m not sure 🤷‍♀️

I hope you’re right and we do get a happy ending from all of this though. There’s a bit of me that just feels like giving up is just not an option given how much has gone into this already!!

Good luck to you too lovely xxx

[Booda21 in reply to BetsyBo]

Oh I know it’s ridiculous isn’t it. I did the era after my 3rd failed transfer. So this time it’s pgt-a and zymot I’m paying for. Not cheap but if I only end up with one or 2 embryos I am not going to go ahead with the pgta as I will just transfer anyway. Feel like there’s nothing to lose and a lot of money for just one transfer. Last time I had 7 embryos to freeze but don’t think it will be this good an outcome. My consultant has told me I don’t need anything doing with my endo, they don’t even want to scan me prior to treatment which I have requested as I said I don’t want to get to the point something is cancelled because the cysts have gotten worse. Which is definitely a possibility as they sprung up pretty quickly! I’m NHS so feel like you just get what you’re given. I could be wrong but I do feel like no one listens to me, the communication is very poor and it’s all so frustrating! I’m sure if I was paying full whack they would listen to me and I would probably have more balls to demand things but feel as most of it is funded I don’t have that luxury! It’s so frustrating isn’t it. You’d rather they just be upfront and honest if it’s never going to work or very slim chances just let me know so I can make an informed decision.

Anyway enough of the negativity! Definitely don’t give up, it can happen. And the biggest fingers crossed that it does 🤞🤞🤞🤞 xxx

[Nuszkahope in reply to Booda21]

I had 2 endometriomas with my last successful cycle so try not to worry x The only annoying thing is that they never go away on their own, I still have them post birth 😔

[MrsOrangejuice]

This may be very basic but have you looked at progesterone resistance/oestrogen dominance? It's common with endometriosis - even when it's 'silent' or the lesions have gone. We were successful immediately (BFP at 3dp5dt) when we changed form of progesterone and upped the dose - that was after 7+years TTC and unexplained infertility without a sniff of a BFP, then 2 rounds of IVF and two early losses from those. I've had endo and gynae issues since I was a child but the hormonal imbalance was never taken seriously. Your progesterone blood levels can be sky high (mine have always been fine during luteal phase and were on cyclogest, but I still spotted) but not getting where it's needed so vaginal pessaries and injections can be better. May not be relevant but also the progesterone changes and higher doses don't hurt according to my consultants so something to consider adding in on off-chance.

[Nuszkahope]

I got my daughter after transfer no 13 x good luck 🤞

[BetsyBo in reply to Nuszkahope]

That’s incredible- what do you think helped you to keep going at the times it hadn’t worked ?xxx

[Nuszkahope in reply to BetsyBo]

I really don’t know. I did PGTA testing and was transferring only healthy embryos x

[Nuszkahope in reply to BetsyBo]

Sorry I didn’t read the message properly… I am a bit busy today. I somehow knew it will work out for me so I kept going. I just refused to lose hope or give up, I am quite a strong and determined person, I just always keep going in life no matter what 🤷‍♀️

[Nuszkahope in reply to BetsyBo]

But I understand that I am privileged, I could afford it financially. I understand it is not the same for everyone 😔

[IVFat40]

I've been successful with the 8th embryo I've transferred, first 7 embryos failed. For me I think the difference was uNK cell testing and steroids as a result. I also did ERA (and prior to that a punch of implantation failure blood tests but they were all normal).

[BetsyBo in reply to IVFat40]

Ahh congratulations and thanks for sharing. The more stories I’ve read makes me think I’m on the right side of the number now 🤞🤞🤞 we’ve paid for another cycle so we shall see what this next one brings xxx