All my eggs failed to fertilise with ICSI second time round

[Ljayne]

This was our second and final fresh go at retrieving and fertilizing my eggs. I have stage 4 endometriosis and PCOS. My husband has low sperm motility so we had ICSI.

My first round of ICSI we got 8 eggs, 5 were mature ad 4 fertilised. 3 embryos failed to implant and one successfully did but when I went to have my 12 week scan, I sadly had a missed miscarriage.

This time round we had 6 eggs, 5 were mature and out of those they failed to fertilise.

I was so pleased we had 6 eggs to begin with as I wasn't expecting that, partly as my right ovary was a no go.

We received a call from our embryoligist this morning to say that none had fertilised. She was shocked as I was fine last time and asked whether anything had changed from last time such as medication, but nothing has changed. The only difference is that I upped the dose of my Gonal F injection which if anything helps.

The embryoligist is going to speak with my fertility doctor today to see if they can come to a conclusion and in the meantime has said that she'll monitor these for the next 24 hours as there is such thing as a late fertilisation.

Has anyone experienced this or can share any stories?

[DianeArnold Partner Nurse Fertility Network UK]

Hi Ljayne. I was so sorry to read this. I wondere whether something like an IMSI cycle would be better so they can see the inside of the sperm better. Perhaps even a sperm fragmentation check? Hopefully your embryologist can come up with a solution. Thinking of you. Diane

[DJ202]

Hi Ljayne,

So sorry to hear about your MMC and the non-fertilisation! It's heartbreaking!!

I've been in a very similar situation to yourself - first cycle 7 eggs, 1 pgta normal tested frozen embie. Second cycle 3 eggs of which none fertilised! Was completely devastated. The doctors assumed it was a problem with egg quality (I'm 38 with diminished ovarian reserve). I think this is an overly simplistic explanation. We also have pathological sperm (low morphology and low motility). Sperm dna fragmentation was OK. They're currently doing a study at Oxford uni looking at protein in sperm that activate the egg which I think might have been the problem for us - we'll have results in a few weeks. I'll keep you posted! What are you planning to do? Let me know what your doctors say, keeping my fingers crossed for you!! xxx

[soccerkt6 in reply to DJ202]

Hi lovelyDo you mind me asking how you got enrolled in the study at Oxford? I’d be keen to see if we’d be eligible. Thanks! xx

[DJ202 in reply to soccerkt6]

Hi soccerkt6, I sent an email to the coordinator and she got us in! You can find more info here: tfp-fertility.com/en-gb/res... do let me know how you get on! x

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So sorry to read this.

Has your hubby been ill recently? We had one disastrous round and we found out afterwards my partners flu 3 months earlier could have been responsible x