I have now had 3 cycles with failed fertilisation: 2 were IVF and the last one was ICSI with AOA. Each time, there were only 2 mature eggs retrieved due to very low AMH.
* In the first IVF cycle, the eggs degenerated.
* In the second one, one egg out of 2 fertilised but abnormally (4 pro nucleus, probably several sperm entered at the same time).
* In the ICSI cycle, the eggs were mature and healthy but neither of them fertilised.
My partner sperm is good quality on all metrics.
I was on the short protocol (“cetrotide”) for all but I managed to create embryos with that protocol before.
My clinic cannot explain why fertilisation stopped working and why there was no success on ICSI with good sperm. Did anyone have a similar experience or any idea of why it failed? What to do differently next time?
I take all the possible supplements (dhea,q10, melatonin, folic acid, cit D, etc) already. My partner sperm had perfect parameters for all cycles.
We know it can work as we created embryos with IVF before the lockdown with the same protocol (same dosage of meds).
The only difference I had is that I was taking prednisolone before the lockdown but I don’t think that helps fertilisation?
Can you share any advice/top or ideas?
Has anyone been through total fertilisation failure with ICSI?
N.B: Please don’t suggest donor eggs.