Imsi

[Tilly8135]

Hello, has anyone had imsi on top of icsi and it has worked?

[HaveFaith1]

Hi Tilly, I haven't but I'm intrigued what it is? Good luck xx

[Llizzie]

Hi Tilly. Yes me and my husband had it. It is labelled as Amber by the HFEA I believe as there isn’t yet enough research to prove it helps. But with severe male factor we decided to throw everything at it. We asked for it - I didn’t feel pressured by the clinic. We got 14 eggs, 12 mature, 8 fertilised, 1 day 5 4AB blastocyst and 2 morulas not good enough to freeze. We had a big fall off, which I expected with my husband’s numbers, but our blastocyst stuck and I’m 17 weeks pregnant. I can’t tell what helped but we got one good sperm! x

[Tilly8135 in reply to Llizzie]

That is fab news, did you have treatment in the U.K.?xx

[Llizzie in reply to Tilly8135]

Yes we did x

[LCharlton]

We did, it didn't make a difference for us unfortunately x

[SCHNOW]

It works for us too! My husband has high DFI above 40%. We did both ICSI and IMSI, which IMSI doubled the blastocysts numbers we could obtain than ICSI. The recent cycle we even asked for PIMSI which gave us 3 PGS tested embryos and the first one worked and I am 13+ weeks pregnant now. Really worth to try if the male factor is the main infertility issue but firstly please eliminate other female factors. While we were using IMSI, I didn’t know I have high NK cells which can cause early miscarriage/chemical pregnancy, wasted a couple of good quality embryos. This successful cycle we used PIMSI PGS and immunology treatment together!

[Tilly8135 in reply to SCHNOW]

Hi, thank you for your reply, where did you go for treatment and how did you find out you had natural killer cells? And congratulations 🎉 xx

[SCHNOW in reply to Tilly8135]

I am with a clinic in London. We can not mention the clinic here, I can PM you if you need. Because I had recurrent miscarriages so I was under detailed investigation at my clinic, I did the tests of ERA EMMA Alice and NK cells biopsy and blood which found out I have high NK cells then I went to miscarriage center for the detailed check of immunology and treatments.

[OneDay79 in reply to SCHNOW]

Congratulations on your pregnancy. Im also considering PIMSI. Was initially considering going abroad but with covid I’d now prefer to stay home. Could you pm details of your clinic please?

[lisaba in reply to SCHNOW]

Congratulations on your pregnancy!! Can you PM me the clinic too? We also have male factor with high DNA fragmentation and have done a few rounds of treatment without success. Thanks!!

[Tilly8135]

Hi Lisa, have you ever tried imsi?x