Cytoplasmic Transfer abroad for Low AMH/older women

[babycometrue]

Hi everyone, when I registered here a month ago I was totally new and had no idea of anything..I devoted my days to read and think .I come to some conclusions of my body/our bodies and our biological clock and start feeling extremely sad, lonely , hopeless, blaming myself why I left it until now when I reached age 45.

So I just chat with clinic abroad and my AMH is 2.3 ( which google say can actually fluctuate, i wonder if i do one more test different place) They asked me if i have heard of Cytoplasmic transfer. Has anyone done it? It is something mixing my eggs with younger woman egg plasma.

[Lenz56]

Ive never heard of this but it sounds like something worth trying.

I have an amh of 2.3 diagnosed at 32.

[LuxFleur]

Wow, that sounds interesting but also extremely expensive! I have also seen in the scientific literature that the process can improve egg fertilization rates, but did not necessarily improve the pregnancy and live birth rates in older women (Cytoplasmic Transfer Improves Human Egg Fertilization and Embryo Quality: an Evaluation of Sibling Oocytes in Women with Low Oocyte Quality, Sobek et al, 2020). There was a high fertilization rate in some cases (up to 85%) but a much lower baby take-home rate (as low as 6.4%!) Also, for pregnancies that were detected, there was an extremely high rate of miscarriage, 33-35%. These are usually due to embryo aneuploidy (a fatal trisomy), the risks for which increase dramatically with parent age. Aside from all this, it looks like you would have to go to Russia or Israel to get it done for age-related reasons (someone correct me if I'm wrong), and I know you mentioned being on a budget.

I know you didn't ask for advice, but if you are set on using your own eggs, it seems your best bet is to try one or two IVF/ICSI cycles with a clinic or doctor that specializes in treating older women. Go somewhere that will test your embryos if you get any, so you don't have to waste time with the transfer of an aneuploid embryo that might implant but not survive. (MOST kinds of aneuploid embryos will ALWAYS result in miscarriage, there is nothing that can be done.) Then you'll get an idea of what you're really working with, because I think you can't know before you actually do a cycle. Some women will perform better than their AMH and FSH would suggest, and some will perform worse. You never know, you could be the surprise exception in your age group.

If you are still able to produce viable embryos, that is great—you're in with a chance. But if not, you can move on to donor eggs. All these actresses doing IVF to have babies at 46, 48—most of the time they are using donor eggs. If not all the time. Having a baby with your own eggs after age 43 is sadly very rare. Best of luck Xx