Can estrogen priming cause sleepy ovaries or negatively affect ivf cycle

[letro112]

Hi all

Due to start estrogen priming and just want to get some more info before we begin. As the question above states I'm worried the estrogen priming will have a negative affect on my upcoming cycle.. any thoughts or experience? X

[Titawine]

I did an estrogen priming before stimulation because I used to have folicule that grows too fast and big sometimes that it turns to Cyst, don't worry you will have a scan in day two of your cycle, your ovaries will look calm and then you will begin your injections. Good luck 👍

[DianeArnold Partner Nurse Fertility Network UK]

Hi letro. Just to calm ovaries down so they can check for any cysts before starting stims. good luck! Diane

[Latetotheparty38]

How did you go? I’m about to start this. Did your protocol include human growth hormone (Saizen?)

[letro112 in reply to Latetotheparty38]

So unfortunately for me the priming was a no go .. I seem to function better without the estrogen priming .. I did do testosterone priming. Ended up on last cycle having 12 follies, 10 eggs, 6 mature and 4 blasts .. this was after cycles of 0 .. Best of luck

[TVG30 in reply to letro112]

letro112 Hi letro ….. hope you are well. I was impressed with the blasts you achieved, as I too end up with only 1 dominant follicle with a few slow growing follicles( low AMH of 0.6 pmol) . I start estrogen priming but should that not work, could you explain what testosterone priming is. I hope you are well and youGet your miracle baby xxx

[letro112 in reply to TVG30]

So testosterone can help recruit follicles ahead of stim. If u have very low testosterone it can affect possibly the number of follicles that can respond to the stimulation meds. I had my testosterone checked it was 0.1 .. they like it between 1 and 2 and if possible as close to 2 as possible. I was put on DHEA which increased testosterone really quickly was only on it a couple of weeks before stimming and this was the cycle I ended up getting 10 eggs .. 6 of which were mature and 4 blasts. Next cycle I had my levels checked again and supplemented with alot less DHEA also had less stim meds and got 7 eggs 5 mature and 3 blasts .. so it's def a big improvement from where I started.

I currently have 5 blasts and we are keeping these for surrogacy as I have had alot of CP and MC and all my transfers have resulted in CP also .. so we are hoping out of the 5 hopefully at least 1 will make it with our surrogate

[BBHH1]

Priming is good quiet the ovary to synchronize better the follicles but is not as aggressive as other medications used in a suppressive phase in some protocols. Best