Karyotype tests

[Rainbowhope]

Hi All

This weekend we had an appointment with our,i ice to discuss our last ivf failure. It was a really difficult appointment because they couldn’t provide any real reason as to why I have repeated implantation failure. They recommended I try again. However, doing the same thing over and over again and accepting a different result seems like madness to me.

One of the things they have recommended is a Karyotype type test. They said this would rule out chromological problems. In the same breath they said we are not likely to have an such difficulties because because we have produced 7 blasts thus far. Has anyone had this and was there any benefit?

I have discussed donor eggs but the clinic but they keep telling me I am too young. I am 36. Moreover, they said we might need to consider embryo adoption. I have no idea why thing was mentioned considering they have never suggested there is a problem with my husbands sperm. Does anyone understand this?

[Hidden]

Sounds similar to our situation and so frustrating!! Donor eggs aren’t always the answer, I had more bfns with them than my own eggs! Have you been assessed for blood clotting issues? Thyroid? I had 5 miscarriages before they tested me for this and taking Clexane 60 daily has helped me hold on to my current pregnancy. Before we did ivf in the States we had full karyotype and consyl tests which showed my husband was a carrier for Cystic Fibrosis but because i’m not that’s fine. There could be something and it’s definitely worth doing! Not cheap though but nothing to do with this is. Good luck xxx

[Cinderella5]

Im a bit puzzled too that DE have been suggested when you are getting good blastocysts. I was always told that due to us getting very few blastocysts that there was likely an egg problem which is why we moved on to DE - we only got 3 blastocysts from 2 cycles but Im older than you. My hubby had karyotyping done but this was due to the fact that he had a very low sperm count and didnt shed any light as his results were normal. Have you had a hysteroscopy to check your uterus? Have they mentioned NK cell testing or even trying steriod cover or intralipids to see if your body is maybe attacking the embryos. This is the route Ive been going down. All in all it could just be bad luck as I do think this treatment is a massive lottery/numbers game. As for them suggesting embryo donation Ive not got a clue why they would even mention this!! I think you need to prod them with more "why" questions! Good luck!xx

[NDE1987]

Hiya, I am so sorry to hear it didn't work out for you. How many implantation failures have you had? I had my NK cells tested and fell my 3rd cycle worked because I was put on a low dosage of steroids from day of transfer. I travelled from London to Warwick and Coventry hospital. You can self refer and the tests cost £540 for 2 biopsys. Please feel free to private message me if you need any more advise x

[Lizzielizzielizzie]

Hi rainbow hope, you can read my story on my previous posts. Karyotyping gave us our diagnosis despite my husbands sperm count and motility being good, turned out he carries a chromosome translocation. At the point we were tested we had had two failed rounds and one natural miscarriage in three years ttc. We had been told it was probably egg quality, but had the karyotyping anyway and I’m so glad we did as I’m now 19 weeks pregnant from a third, funded round of ivf (there’s nhs funding for chromosome translocations) where they tested our blastocysts. It’s also meant others in hubbie’s family being diagnosed, hopefully saving them years of infertility heartache.

[MofM in reply to Lizzielizzielizzie]

(Rainbowhope, sorry for taking advantage of your post)

Hi Lizzie, sorry to hear about your losses. I may need to do IVF abroad and they are asking for a Karyotype test. How have you had your done? Was in on the NHS? Do you know if it can be done privately (and how)?

[Lizzielizzielizzie in reply to MofM]

We paid our uk ivf clinic privately. They then sent our bloods off to California I believe! But our family members had it done on the nhs after referral to a genetic counsellor by their gp- but that’s because there was a recognised reason for it, ie my husband had been diagnosed with an inheritable condition by then. The other times I’ve heard of people having it done on the nhs are in cases of recurrent miscarriage or azoospermia. I think if you post your question asking for help from others who have used clinics abroad, they will be better placed to help you.

[MofM in reply to Lizzielizzielizzie]

Thanks!