Side effects of Bempedoic Acid

[RestlessOwl]

I have high cholesterol and reacted badly to 2 statins so was given ezetimibe a year ago. This hasn't reduced the cholesterol enough so now started on Bempedoic acid in addition. I read it might also help improve fatty liver, which I also have. Feel very bloated and tired after 2 doses. Does anyone have any experience of this medicine?

[nash2 Partner]

no personal experience, but perhaps a question for your doctor. If you have an at risk liver, it is worth noting that Bempedoic is an additional work load for the liver as that is where it is converted to its active form. Common adverse effects in clinical trials were muscle spasms (3.6% of treated patients, as compared to 2.3% under placebo), pain in the back (3.3% versus 2.2%) or in a limb (3.0% versus 1.7%), gout (1.5% versus 0.4%), and gastrointestinal problems such as diarrhea. A less common but more serious adverse effect was tendon rupture in the rotator cuff of the shoulder, the biceps tendon or the Achilles tendon (0.5% versus 0.0%).[2]