Dr Michael Mosely's 5:2 diet is not Intermittent Fasting (well - not much more than not eating while you are asleep).
Eating 500 or 600 calories a day will prevent autophagy and most of the benefits of Intermittent Fasting. Does he suggest you eat all your "fast day" calories in one meal? Fasting One Meal A Day (OMAD) which would be beneficial.
Fasting (e.g. 36 hours) two days a week would be effective - but you might want to get into "fat-burning mode" before trying it.
Have any of your tried 5:2 - and what were your experiences?
I fast two days a month. This is a 68 hour fast, as I normally fast 20:4 - and 20 + 48 is 68!