Sorry to bother you all feel really weird after zoladex, any advice? Please.?

Had zoladex monday and other than soreness felt ok but feel really bad this evening. Any advice?

[Impatient]

Get to bed and rest and see how it pans out through the night. The zoladex will be beginning to now put you in to th flare stage - where your body is super overloaded with so many hormones than in a week or so time it will cause the pituitary gland in the brain to shut down working. It is meant to do this.

For some the flare stage is the worst bit

For others it is just the start. These are very powerful drugs, cancer drugs, and you cannot avoid having the next few weeks of experience whatever the drug throws at you.

My advice is rest and relax as best you can and try and get some sleep. Do not go in to work if you are feeling bad. You do not have to attend work any days you are too unwell to attend.... and there could be many such occasions.

If at the end of the month you really cannot face another month of potentially similar side effects then don;t have the next implant.

It is meant to improve your quality of life - but it seems in more than half of cases that doesn't happen and it makes things worse. It doesn't cure endo so you are only taking it in the hope it does improve how you feel and if you do react badly to it - which many of us do- then you need to decide whether you ca cope with a month more of the same or worse or whether that was enough and you allow the drug to work its way out of your system and you get back to normal you.

[Hidden]

Thank you. Work is unavoidable as will lose my job if im off again. But will try rest. Thanks again

[esbjorn]

Dear Septimus

wishing you all the best. I started my GnHR injections on 10th December. I had a bad flare up with my first injection which lasted about 4 days (had injection Wednesday, started feeling really bad Friday, in bed Saturday & Sunday, better Monday (went to work) and recovered by following Wednesday). The flare ups appear to be getting subsequently better - only 2 days for the last two injections and not as bad as the first one. Towards the end of December i had 4 almost 5 days WITHOUT ANY pain for the first time in 2.5 years. And I've got my energy back - just don't overdo it -just because you may start to feel better - take it easy, you may still have scarring that means that you may still not be able to clear out the outhouse, mow the lawn, carry 8 shopping bags without feeling the pain coming back. Hopefully however you may feel your energy levels increase and the inflammation & inflammatory pain decrease (or - fingers crossed - cease completely).

After my second injection the hot flushes started - I'm really enjoying them though Before the GnRH injections I was constantly cold, slept with two duvets, PJ & fleece jacket.. Now I it's back to one duvet! And I don't have to wear 4 layers of clothes, fleeces, woolly jumpers etc at work & home..

Apart from the hot flushes, I have started to feel WELL most days - a strange feeling in the beginning. I still have to take the occasional painkiller & NSAID & digestive medication. My drug consumption however is down by almost two thirds. I have just asked to continue my treatment for another 3 months (to take it up to the maximum of 6 months).

Wishing you all the best Good luck xx

[Hidden in reply to esbjorn]

Good evening. How are you on the GNRH drugs?

[esbjorn]

Hi

I'm doing well thank you, although towards the end of the month (just before the next injection) symptoms start to creep back up again. Had my 5th injection Tuesday gone, the customary flare up (increasingly shorter though) followed approx 24-36 hours later - in bed for 12 hours solid but fine again since Fri pm/Saturday. This spring my energy is back to normal, have cleared the guttering (for the first time in 3 years - needed doing..), cleaned all our windows (even the roof ones..), mowed the lawn without being bedbound the following day - fantastic; all the things I normally do! I have got my life back.. still the odd ache & pain & inflammatory flare up & still have to use some NSAID, paracetamols & codein but hey.. Hot flushes galore however to me - compared to how ill I was and the level of chronic everyday pain I had before the GnRH - they are a small price to pay. BUT we're all different and hormones & pain work on different levels in all of us.

How are YOU?

xx