Obesity associated metabolic disease linked to malfunction of liver immune system leading to insulin resistance .

[patliputra]

diabetes.co.uk/news/2017

Researchers at university of Toronto have found that certain white blood cells in the liver can go rogue and can cause insulin resistance in patients with non alcoholic fatty liver disease.

Liver CD8+ T cells play an important role in fighting viral infections. But as fat accumulates in liver with obesity or NAFLD, they are programmed to increase blood sugar and worsen insulin resistance.

Once activated CD8+T cells release inflammatory molecules called cytokines that cause inflammation . This inflammatory state is intimately linked to insulin resistance.

This pro inflammatory response can disrupt or block insulin signalling to liver. This can cause liver to continue pour more sugar into blood stream and resulting in inability to regulate blood sugar.

The research tends to suggest that inflammation is emerging to be a major mediator of insulin resistance and mal function of liver immune system may be developing link.

[rvmasalvad Volunteer Star]

what are the obesity associated metabolic diseases?can you name a few?

[patliputra in reply to rvmasalvad]

DM2, hypercholestolaemia, hyper triglyseridemia.

[rksharmakumar in reply to patliputra]

In Diabetes it is said,"cell have becomes insulin resistant "But on the other hand it is said in a layman language that cells dies after some times and New are born,then how the cells becomes insulin resistant when they dies to be replaced by new born,/ Puzzle the mind,any explanation/

[patliputra]

Very good question. Thank you . I am going to answer it in a general way. I am not a cell microbiologist.

Have you ever thought how dead cells are replaced ? For the replacement of dead cells body uses a process , a type of cell division called MITOSIS. In process all the genetic material is equally divided. So both the daughter cells are exactly same and inherit all the properties of mother cell. The is why new cells are also insulin resistant.

Equally divided =equally duplicated.

[rksharmakumar]

OK,convincing answer.

[rksharmakumar]

Thanks

[suramo Star]

patliputra

Very weird thinking by the scientists. Obesity and nafld are the result of IR. White cells are part of immune system. Don't think they are causing IR. The article itself is selfcontradictory.

[patliputra in reply to suramo]

That was research paper. I have nothing to add or subtract. You expressed your personal opinion.

[suramo Star in reply to patliputra]

patliputra

There is nothing personal here. Thanks for sharing.