What exactly are the differences between these two forms of medication - their action on the body, effects etc.? I had been on metformin for several years to control my type 2 diabetes. About 2 years ago the doctor asked me to switch to Dibizide M 1/2 - 0 - 1/2 and metformin (250) 0 - 1 - 0. Since taking Dibizide M I have been experiencing hypos if I do not eat something within 2 hours of breakfast. I am not aware of the same thing after dinner. This is a problem I had never had while taking metformin alone. The other meds I take are Telpres CT 40/6.25 for BP and Ecosprin AV 75 for cholesterol. I am a poor practitioner of the LCHF diet. Is it the destiny of type 2 diabetics to graduate to sulphonylurea as the disease progresses?