Diabetes India
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Novel CoQ10 Antidiabetic Mechanisms Underlie Its Positive Effect

Prevalence of insulin resistant (IR)/type 2 diabetes nowadays depends on the slothful life style on one side and on the high intake of “Westernized” diet, which deemed to be the main environmental trigger [1], [2], on the other side.

Pathogenesis of this metabolic disorder emerges from a complicated interplay between several factors, including mitochondrial dysfunction that lies somewhere along a continuum from genetic to environmental abnormalities. Several studies have pointed to the paramount importance of the mitochondrial dysfunction in different metabolic disorders including IR/type 2 diabetes [3], [4]. Mitochondrial dysfunction was found to be an underlying mechanism and a complication of diabetes, with a major role played by oxidative stress [5]. Hence, treatment or supplemental strategies that contemplate on improving mitochondrial function and constraining oxidative stress might present important prospect.

Read further here

ncbi.nlm.nih.gov/pmc/articl...

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Also read..

Many studies suggest a central role for oxidative stress in the pathogenesis of this multifaceted metabolic disorder. This has prompted investigations in the use of antioxidants as a complementary therapeutic approach [Golbidi et al., 2011]. Serum CoQ10 levels in type 2 diabetic patients are often decreased and may be associated with subclinical diabetic cardiomyopathy, reversible by CoQ10 supplementation [Miyake et al., 1999]. In 3 separate randomized, double-blind clinical trials, a total of 194 dyslipidemic type 2 diabetic patients received 200 mg CoQ10 or a placebo daily for 12 weeks. One study also compared CoQ10 stand-alone treatment to a CoQ10-fenofibrate combination and to fenofibrate (a lipid-lowering medication) alone.

ncbi.nlm.nih.gov/pmc/articl...

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Originally going to reply to this:

Blah, blah, blah whether it supports my view or not

However, on reflection, give me a break!

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Too much, this will not help anyone looking for answers!

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Certainly !!.....only Basilisk will lead them to answer.....

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@anup I feel improvement in mitochondrial function will be one more avenue to control blood sugar.

It is said shilajeet works /enhances the action of coq10.

LOL...but after many years or follow up.... I am still confused what shilajeet means..... :D organic or inorganic....how it is procured....how and what process is involved in purification....so many things....

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but guess we can get good quality coq10

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God knows @anup we really don't know what is real shilajeet...and how to test the same....

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hmmm yes @anup what you recall is right...

When I was in school..on my way to school there were few road side Vaida selling 'Sande Ka tail' and sheelajeet for 'EXTRA POWER' lol....

They use to shout..." babuji....ye pathhar ka paseena hai...himalay ki choti se aya huwa kajana hai"

LOL....

In russian it is called mumuye....it is said in certain areas of himalaya in summer you find this substance in cracks formed in rock.....it contains fluvic acid....humic acid...

Humic acid is something you can find in many things...Humic acid is also used as fertilizer.

But no one is sure about how it is formed.

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Oh yeah...fresh curcuma amada and curcuma longa are still available here in local market....

Yesterday only made pickle of same ....which will last me till end of august...and by then i will get fresh supplies of same....

hmmmm do u know about one more wonder drug from Himalaya like shilajeet???

Yartsa Gunbu/winter worm....

Read here....

en.wikipedia.org/wiki/Ophio...

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"fresh curcuma amada and curcuma longa"

IS it available in Mahatma Phule mandai ?

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yes

Only at one place....if u like plz contact me on monday...I will take u to that shop

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Not possible for me on Monday but later in the week.

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just add some crushed black pepper....it is said it will increase bio availability of curcumin....

Further...I am trying to get black haldi this season.....black haldi contains atleast double curcumin than any other species...

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Great......try this curcuma amada.....ambe halad..... it will help to bring down TG

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Hmmm @anup ek bat batao yar...

Ye log bolte hai....ek gm fat liver se jayegi toh tum think ho jawoge....

Now With LCHF I am sure fat melts....toh yar...ek gm liver se nahi jati???

U follow this keto diet for so long....i don't think any fats in ur liver now....

Kya manjara hai ye???

I am confused...

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precisely that's my point and doubt .

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hmmmm yes @anup you are right...

Newcastle was for high BMI ppl....

And is there any way we can improve first phase of insulin response???

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cure @anup

According to the New Castle study, insulin secretion returned to normal after the participants lost about one gram of fat from pancreas. They lost lot more fat from liver before their FBS normalized. Those who got their diabetes in remission still remained obese. They were asked to consume 2/3rd of calories that they consumed before the experiment to keep fat from accumulating in their liver and pancreas again.

Interestingly, not all obese people have liver and pancreas clogged with fat. While many slim people have.

In an online Q&A session, Dr. Taylor opined that losing fat from liver and pancreas is the key, and it could be achieved with any diet regime, even LCHF. They chose hypocaloric diet because they were mimicking bariatric surgery where the patient can consume very few calories.

BTW, with this diet they did not observe any improvement in peripheral insulin sensitivity.

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Very true.....

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Or fasting is stomach stapling without surgery and associated complications. :D

Nobody in his right mind would(should?) suggest bariatric surgery to a diabetic given the risks and complications, when the same benefits can be obtained from fasting.

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Guess now days this is covered in medical insurance in western countries...

earlier it was not

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Has there been a systematic study on the stomach stapling surgery?

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it is said about 65% population gets cured

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I meant studies on risks and complications of bariatric surgery.

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yes...and less risk

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Remission for 3 years is significant. One can still adopt a low carb diet to avoid weight gain.

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What exactly happened to her after the surgery? Any idea?

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AFAIK, the surgery costs a bomb.

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The deceased was a qualified doctor herself. She weighed 75 kg and still underwent weight loss surgery! She should have known better.

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No...Don't have idea....but hmmm command hospital means he must be looking for cheap option....

And it happens...when civilians visit command hospital all chances that new trainees practice on those cases..

But even case is successful.... in longer run...these patients will face problems due to malnutrition....

Science is still searching for many secretes of body.... many things are unknown....

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