Prevalence of insulin resistant (IR)/type 2 diabetes nowadays depends on the slothful life style on one side and on the high intake of “Westernized” diet, which deemed to be the main environmental trigger [1], [2], on the other side.
Pathogenesis of this metabolic disorder emerges from a complicated interplay between several factors, including mitochondrial dysfunction that lies somewhere along a continuum from genetic to environmental abnormalities. Several studies have pointed to the paramount importance of the mitochondrial dysfunction in different metabolic disorders including IR/type 2 diabetes [3], [4]. Mitochondrial dysfunction was found to be an underlying mechanism and a complication of diabetes, with a major role played by oxidative stress [5]. Hence, treatment or supplemental strategies that contemplate on improving mitochondrial function and constraining oxidative stress might present important prospect.
Many studies suggest a central role for oxidative stress in the pathogenesis of this multifaceted metabolic disorder. This has prompted investigations in the use of antioxidants as a complementary therapeutic approach [Golbidi et al., 2011]. Serum CoQ10 levels in type 2 diabetic patients are often decreased and may be associated with subclinical diabetic cardiomyopathy, reversible by CoQ10 supplementation [Miyake et al., 1999]. In 3 separate randomized, double-blind clinical trials, a total of 194 dyslipidemic type 2 diabetic patients received 200 mg CoQ10 or a placebo daily for 12 weeks. One study also compared CoQ10 stand-alone treatment to a CoQ10-fenofibrate combination and to fenofibrate (a lipid-lowering medication) alone.
@anup I feel improvement in mitochondrial function will be one more avenue to control blood sugar.
It is said shilajeet works /enhances the action of coq10.
LOL...but after many years or follow up.... I am still confused what shilajeet means..... organic or inorganic....how it is procured....how and what process is involved in purification....so many things....
When I was in school..on my way to school there were few road side Vaida selling 'Sande Ka tail' and sheelajeet for 'EXTRA POWER' lol....
They use to shout..." babuji....ye pathhar ka paseena hai...himalay ki choti se aya huwa kajana hai"
LOL....
In russian it is called mumuye....it is said in certain areas of himalaya in summer you find this substance in cracks formed in rock.....it contains fluvic acid....humic acid...
Humic acid is something you can find in many things...Humic acid is also used as fertilizer.
According to the New Castle study, insulin secretion returned to normal after the participants lost about one gram of fat from pancreas. They lost lot more fat from liver before their FBS normalized. Those who got their diabetes in remission still remained obese. They were asked to consume 2/3rd of calories that they consumed before the experiment to keep fat from accumulating in their liver and pancreas again.
Interestingly, not all obese people have liver and pancreas clogged with fat. While many slim people have.
In an online Q&A session, Dr. Taylor opined that losing fat from liver and pancreas is the key, and it could be achieved with any diet regime, even LCHF. They chose hypocaloric diet because they were mimicking bariatric surgery where the patient can consume very few calories.
BTW, with this diet they did not observe any improvement in peripheral insulin sensitivity.
Or fasting is stomach stapling without surgery and associated complications.
Nobody in his right mind would(should?) suggest bariatric surgery to a diabetic given the risks and complications, when the same benefits can be obtained from fasting.
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organic or inorganic....how it is procured....how and what process is involved in purification....so many things....
Dietary carbohydrate restriction as the first approach in diabetesmanagement: Critical review and evidence base
