There have been extensive studies of pancreatic islets , liver , fat cells as well as brain , gut , vasculature and muscles. Evidence now exists to support an important role for each in metabolic homeostasis and for a causative role for several organs in both diabetes and obesity. Many treatments for obesity and diabetes have focused on the role of diet and physical activity. Most pharmaceutical research focused on control of food intake, increased energy expenditure or improving insulin action. But DESPITE EVIDENCE TO SUPPORT THEIR UTILITY, THEY HAVE NOT YET SLOWED THE GROWTH IN RATES OF OBESITY OR DIABETES.
Perhaps the time has come to expand our research to carefully investigate the environmental changes that have accompanied the epidemic of obesity and diabetes.
What are those environmental changes we should take into consideration ?