Prazosin for RBD?

[AkunaMatata]

Interesting paper from 2024: A case of prazosin in treatment of rapid eye movement sleep behavior disorder ( jcsm.aasm.org/doi/full/10.5... )

"We report a case of successful RBD management with prazosin in a patient in whom high-dose melatonin was ineffective. Although there was no observable reduction in dream-enactment behaviors with high-dose melatonin, the possibility of a synergistic effect of prazosin combined with melatonin cannot be ruled out. This case report supports further evaluation of prazosin as a potential therapeutic for RBD."

They used melatonin 9 mg + prazosin 5 mg at bedtime.

Prazosin is an alpha-blocker used to treat hypertension, enlarged prostate, and nightmares related to PTSD.

What is interesting is that terazosin, another alpha-blocker, is studied in Parkinson's with a trial about to start in the UK (EJS ACT-PD): isrctn.com/ISRCTN17799294

Both terazosin and prazosin activate PGK1 and enhance glycolylis: mdpi.com/1422-0067/23/1/416...

[Bolt_Upright]

Thank you for sharing. This is a very interesting article.