Ibuprofen intake might protect against Parkinson's disease

[Farooqji]

Studies have found that one of the key hallmarks of patients with Parkinson's disease is the presence of inflammation. Per a 2020 article in Nature Reviews Oncology, researchers discovered that among people who carried mutated variants of the leucine-rich repeat kinase 2 (LRRK2) gene, which is thought to be the most common cause of genetic Parkinson's disease, taking ibuprofen regularly reduced the risk of developing the condition.

Read More: healthdigest.com/1637300/ib...

healthdigest.com/1637300/ib...

[docjleonard55]

I get a lot of headaches. For a long time my go to medication for them was ibuprofen. So I took a lot of ibuprofen over the years. I still got PD.

[Farooqji in reply to docjleonard55]

That was how many years before your diagnosis? I am asking as we know that PD starts 10 to 15 years before diagnosis

[docjleonard55 in reply to Farooqji]

Probably starting taking it in my 20s. Ive gotten headaches my whole life starting in the single digits. So I've been taking it for 40 something years.

[Eryl in reply to docjleonard55]

Shouldn't the correct treatment be to remove the causes of the headaches rther than trying to soothe the symptoms? Headaches are due to inflammation in the brain and the correct way of 'curing' headaches is to not cause the inflammation in the first place youtu.be/BtmQ7132bvY?si=MUD...(Not working as expected?)

[park_bear]

Study here: movementdisorders.onlinelib...

This is an observational study, but very strong odds ratios found:

"Regular NSAID use was associated with reduced odds of PD in the overall cohort (odds ratio [OR], 0.34; 95% confidence interval [CI], 0.21–0.57) and in both pathogenic and risk variant carriers (ORPathogenic, 0.38; 95% CI, 0.21–0.67 and ORRiskVariant, 0.19; 95% CI, 0.04–0.99). Similar associations were observed for ibuprofen and aspirin separately (ORIbuprofen, 0.19; 95% CI, 0.07–0.50 and ORAspirin, 0.51; 95% CI, 0.28–0.91)."

This merits an interventional study on existing Parkinson's patients.

[ghoegap in reply to park_bear]

Would/could this suggest PWP taking ibuprofen to slow progression or mitigate symptoms?

[park_bear in reply to ghoegap]

It certainly suggests that to me! Why I believe an interventional study is in order.

[gomelgo]

association is not necessarily causation right?

[Eryl]

Anti inflammatories are a short term solution i.e mainly for treating acute injuries. PD is not an acute injury and the causes are not trauma so the solution is not to treat with anti inflammatories but to try to remove all possible causes of the inflammation, Things like environmental toxins or processed food.