The Epidemiology of Parkinson's Disease

[SilentEchoes]

I live in the Red River Valley - a neurodegenerative disease hot spot. This isn't where I was poisoned, it's where we landed after I got sick. I had to be transferred by ambulance to a different hospital system in May - there are specially trained teams for patients with ALS due to respiratory failure. I'm glad they're available, but this is an anomaly that doesn't exist in the Twin Cities metro area.

Parkinson's is twice as likely to strike whites and Hispanics as blacks and Asians. These are the populations most heavily involved in commercial agriculture. Parkinson's is more common in the Midwest and the Northeast, these are the two regions of the country most involved in metal processing and agriculture, and chemicals used in these fields are the strongest potential environmental risk factors for Parkinson's disease identified so far.

Genetic factors explain only a small percent of cases. Environmental factors are likely more common contributors and may include prolonged exposures to herbicides and insecticides used in farming or to metals such as copper, manganese and lead.

medicalxpress.com/news/2010...

People who have been exposed to low levels of pesticides were found to be 1.13 times as likely to have Parkinson's disease compared with those who had never been exposed. Those who had been exposed to high levels of pesticides were 1.41 times as likely to be affected. medicalxpress.com/news/2007...

In the case of Parkinson’s, over 1.5 million people in the US are living with the disease. Men are at greater risk than women (3:2). 60,000 cases are diagnosed each year, and this number does not reflect the thousands of cases that go undetected. The majority of cases occur between the ages of 50-79, with 10% of cases occurring before the age of 40.

The prevalence of Parkinson's disease is rising in younger adults. In 2013 the prevalence rate of PD per 100,000 adults ages 30-64 was 5.5. In 2017 the prevalence rate rose to 8.4 - that's a 53% increase in 4 years. When you narrow the adult age to between 30-50 (early-onset) the prevalence rate goes from 1.21 in 2013 to 2.5 in 2017. This is a 107% increase in Parkinson's disease and it's occurring in increasingly younger ages.

hortzone.com/wp-content/upl...

herbscientist.com/wp-conten...

[park_bear]

Map of Parkinson's distribution here:

healthunlocked.com/cure-par...

[SilentEchoes in reply to park_bear]

If you believe the dogma - permethrine is safe for humans. NOT. Pyrethroid pesticides are synthetic derivatives of natural pyrethrins obtained from the chrysanthemum flower. These compounds have become first-line insecticides for the control of domestic pests. They often replace home and agricultural use of certain restricted or banned insecticides, such as organophosphates (OPP) and organochlorine (OCP).

The method of action and toxicity is the same as OPP and OCP. It's a mitochondrial poison. I'm not saying glyphosate is the only cause of neurodegenerative diseases - it is the most widely used pesticide in the world and ubiquitous in our environment. There's a false sense of security with these chemicals and people can unintentionally poison themselves, their children and their pets.

Exposure to Sub-Lethal Doses of Permethrin Is Associated with Neurotoxicity: Changes in Bioenergetics, Redox Markers, Neuroinflammation and Morphology

ncbi.nlm.nih.gov/pmc/articl...

[park_bear in reply to SilentEchoes]

Permethrin IS a Pyrethroid

It would be unethical to experiment on people to to prove a cause and effect relationship between Parkinson's and permethrin exposure. Here is the next best thing - proof using an animal model:

pubmed.ncbi.nlm.nih.gov/277...

Early life exposure to permethrin: a progressive animal model of Parkinson's disease

"Methods: The permethrin-treated group received 34mg/kg daily of permethrin from postnatal day 6 to 21, whereas the age-matched control group was administered with the vehicle only.

Results: At adolescent age, the permethrin-treated group showed decreased levels of dopamine in the striatum, loss of dopaminergic neurons in the substantia nigra pars compacta and cognitive impairments [characteristic signs of Parkinson’s]. Motor coordination defects appeared at adult age..."

[SilentEchoes in reply to park_bear]

And then there's this. We need to look upstream to understand how this poison acts. Every damn time I look I find cyanide.

Chemical structure of Permethrin

[NRyan in reply to SilentEchoes]

This is exactly what caused my PD. I had to use it for a scabies infection (I worked with a poor population) while pregnant. I developed symptoms quickly of SIGNIFICANT insomnia. It is only 19 years later that I realized the use of the pesticide was what brought on my symptoms. I never realized there was a correlation. Duh!!!! It was so out of the blue that I had no idea where it came from....pregnancy? menopause? genetics? Nope....the Big P. Bloody bastard.

[MarionP]

ALS.

If we are talking strictly Parkinson's, there is a single guilty party that I believe is the one that does it, and very effectively and completely to induce Parkinson's: Paraquat. That's the agricultural chemical that does induces Parkinson's.

The other chemical that induces Parkinson's is what they use to dry clean clothes and other fabrics: trichloroethylene.

[SilentEchoes in reply to MarionP]

My poisoning was reported and investigated by the Minnesota Department of Agriculture. The co-op basically synthesized sarin by combining an organophosphate (Roundup Original II) and an organochlorine (Assure II) plus ammonium sulfate and another surfactant Tradition 93, plus water (hydrogen donor/free ammonia). I don't know how I've survived this long. The neighbors herd of cattle died. The only thing the MDA tested for was glyphosate on my clothing. The MDA committed fraud in their investigation and omitted the first sample of my organic oats (they should have been destroyed) then took samples a week later and used this in their report. The MDA refused to give me the lab report with the level of glyphosate contamination for the first sample set. I still have the oats. I put up a good fight and I'm not done.

[MarionP in reply to SilentEchoes]

Good Christ

[mk2002wi]

GMO foods may be suspect, IMO sustainablefoodtrust.org/ne...

[SilentEchoes in reply to mk2002wi]

It's part of the problem. GMOs are contaminated with pesticides. Glyphosate (it's patented as an antibacterial) destroys the good gut bacteria that is a large part of the immune system.