ATP and NAD+ Deficiency in Parkinson’s Disease

[JayPwP]

Laurie Mischley authored...

ncbi.nlm.nih.gov/pmc/articl...

Results from this pilot study contribute to a growing body of evidence that PD is not a brain disease, but a systemic metabolic syndrome with disrupted cellular energetics and function in peripheral tissues. The significant impairment of both mitochondrial ATP production and resting metabolite levels in the TA muscles of the PD patients suggests that skeletal muscle mitochondrial function may be an important tool for mechanistic understanding and clinical application in PD patients.

[gomelgo]

thank you so much for posting this here!!! I have been intuiting this while watching my own symptoms and it makes a lot of sense.

[JayPwP in reply to gomelgo]

Correcting Mitochondrial dysfunction and increasing cellular energy seems to be the best go forward strategy.

Melatonin, GlyNAC, Ketogenic diet, Niacin should be implemented in daily routine

healthunlocked.com/cure-par...

healthunlocked.com/cure-par...

[gomelgo in reply to JayPwP]

Could you share your source for glynac please?

[JayPwP in reply to gomelgo]

I have started taking 1 cap TMG 1000 mg with NAC 600 mg 2 caps (1200 mg total)

TMG brand Nutrija, NAC Vitacost

[gomelgo in reply to JayPwP]

What is TMG?

[JayPwP in reply to gomelgo]

TriMethylGlycine also known as Betaine

[gomelgo in reply to JayPwP]

Thank you Jay, and how do you feel?

[gomelgo in reply to gomelgo]

Also, links please?

[JayPwP in reply to gomelgo]

Too early to say anything.

I have also started nicotinic acid 100 mg post dinner for the past 3 days and sleep quality seems better

[gomelgo in reply to JayPwP]

I'm just so hesitant to add anything to my very tall stack. Oy ...

[JayPwP]

This is a very interesting paper.

Since Parkinson’s disease symptoms frequently present asymmetrically, especially at the stage assessed in this study, we performed a secondary analysis to test whether the predominantly affected side was more impacted than the less affected side of the body. An analysis was done on the subgroup who reported their symptoms starting on the right vs. left (all our evaluations were done on the right) (Figure S1A). There was no difference in the ATPmax values when compared in this way, suggesting that the decline in ATPmax was not due to a change in muscle activity based on PD symptoms.

[Trig27]

It's becoming more and more obvious that PD is a metabolic disease. The problem is people don't know early enough to change their lifestyle, and even if they do it's hard to do: exercise, fasting, fermented foods, real food...who has the energy for all that? Give me a Hot Pocket, my TV and a pile of supplements instead...

[gomelgo in reply to Trig27]

What's interesting for me is that I have been vegan for over a decade. However, I have a sugar/chocolate addiction. So I am betting that this is a kind of diabetes of the brain, which is one way they describe Alzheimers.

[JayPwP in reply to gomelgo]

PD is referred to as type 3 diabetes by some

[gomelgo in reply to JayPwP]

I want to find a hypnotist to help me stop my chocolate addiction.

[JayPwP in reply to gomelgo]

👁️👁️

Mel, your chocolate addiction is over now!!!

[gomelgo in reply to JayPwP]

It worked! I am now having peanut butter ice cream. lol

[JayPwP in reply to gomelgo]

😆😆😆

[JayPwP]

Found the skeletal muscle reference interesting in the below article and the original post...

ncbi.nlm.nih.gov/pmc/articl...

In conclusion, melatonin was equally effective as alpha-lipoic acid; it exhibited marked antioxidant and anti-aging effects at the level of skeletal muscle in vitro even when it was given in a much lower dose than alpha-lipoic acid.