While the initial causes of Parkinson’s disease (PD) are not clearly defined, iron deposition has long been implicated in the pathogenesis of PD. The substantia nigra of PD patients, where the selective loss of dopaminergic neurons occurs, show a fairly selective and significant elevation in iron contents. However, the question remains whether iron deposition represents the initiation cause or merely the consequence of nigral degeneration. Here, we describe existing findings regarding the interaction of iron with neuromelanin and alpha synuclein, the iron deposition in experimental animal model of PD and sporadic and familial PD patients, and the treatment option involving the use of iron chelators for targeting the aberration of iron level in brain. This review may provide us a better understanding of the role of iron in PD to address the question of cause or consequence.
Parkinson’s disease and iron: While the... - Cure Parkinson's
Parkinson’s disease and iron
Written by
Farooqji
To view profiles and participate in discussions please or .
Read more about...
6 Replies
•
From the abstract you still can't tell if the research separated iron explaining why microbleeds degrade the neurons versus iron degrading the neurons independent of microbleeds.
Here's a link to the full article
drive.google.com/file/d/15m...
My blood panel shows too much iron. What do you thinks the best way to reduce it? Donate blood?
If you are prone to iron overload, you can minimize the risk of health problems by:
1. Reducing your intake of iron-rich foods, such as red meat.
2. Donating blood regularly.
3. Avoiding taking vitamin C with foods that are rich in iron.
4. Avoid using iron cookware.
Not what you're looking for?
You may also like...
Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s disease March 2022
Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s...
Too much Iron is link to Cardiovascular disease, diabetes, cancer, neurodegenerative disease
https://getpocket.com/explore/item/iron-is-the-new-cholesterol?utm_source=pocket-newtab
Just...
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
Niacin
PD patients are found to have significantly decreased niacin levels compared to age-matched...
Parkinsons Disease and Exercise
Physicians tend to underestimate the importance of exercise for combating PD. Their first line of...
High levels of iron
There is a thought that high levels of iron are a underlieing cause of PD. Men have much higher...