Very interesting article: Tetanus Vaccine Decreases Incidence of Parkinson’s Disease and Slows Its Progression 2024 gilmorehealth.com/tetanus-v...
It is based on this paper: Tetanus vaccination is associated with decreased incidence of Parkinson’s disease and slower progression 2024 medrxiv.org/content/10.1101...
Abstract
Parkinson’s disease (PD) is characterized by progressive neurodegeneration in the autonomic and central nervous systems, manifesting with hallmark symptoms of rest tremor and bradykinesia. Its etiology remains poorly understood, and currently available treatments do not halt disease progression.
Here we analyze the impact of vaccination and medication purchase on PD occurrence and disease severity in a national health provider, employing a novel machine learning method.
We show that anti-tetanus vaccination significantly reduces PD occurrence, and that both the rate and severity of PD are strongly associated with the time elapsed since last vaccination. These results, which suggest that C. Tetani toxin is involved in PD pathology, are reinforced by findings that antimicrobial treatments that affect Clostridium species are associated with significant changes in disease severity.
Tetanus vaccination and clostridium eradication are promising strategies to prevent PD and slow its progression, pending controlled trials.
Parkinson’s disease (PD) is a neurodegenerative disorder affecting over six million individuals worldwide (1). PD is characterized by the progressive loss of neurons throughout the peripheral autonomic and central nervous systems. Current diagnosis of PD is based on the presence of rest tremor, bradykinesia, rigidity and postural response abnormalities which are tightly associated with dopaminergic loss. The etiology of PD remains poorly understood, although aging, genetic and environmental factors have been identified as risk factors. Currently, only exercise has shown an effect on disease progression and no approved treatment targets the basic mechanism of the disease or its direct cause.
Clostridia are gram-negative obligate anaerobe bacteria that are prevalent in the environment. Several members of the Clostridium species produce highly potent toxins (2). Notably, C. tetani can produce Tetanus neurotoxin, the causative agent of tetanus (3, 4). In tetanus, the neurotoxin is internalized into signaling endosomes and transported retrogradely to the neuronal soma, interfering with the release of neurotransmitters, notably glycine and gamma-aminobutyric acid, blocking inhibitory impulses(5). Lacking inhibitory neurotransmission, motor neurons stimulation increases, producing rigidity, unopposed muscle contraction and spasm(6)
To protect from the severe risks associated with tetanus disease, the combined Tetanus and Diphtheria toxoid (TD) vaccine is routinely administered to infants, children and adolescents as part of the standard immunization programs(7, 8). Adults usually receive anti-tetanus booster vaccination upon clinical indication, when they present in clinic with a wound susceptible to be infected with C. tetani, and there is no record of vaccination in the last ten years (or five years in a dirty wound at high risk for contamination). In a serologic survey performed in the United States between 1988 and 1994, fully protective levels of anti-tetanus and anti-diphtheria antibodies were detected in 91% of individuals aged 6 to 11 years but in only 47% of individuals 20 years or older (9, 10). Interestingly, PD happens to be diagnosed at the late adult age, typically after 45, when tetanus antibody protection acquired from childhood and adolescence vaccination is no more protective.
Recent studies have revealed significant differences in the gut microbiota composition between patients with Parkinson’s Disease (PD) and healthy controls (11). Notably, alterations were observed for Clostridia species (12). C. tetani have been isolated in the feces from adult individuals (13), suggesting it might be a common host of the human gut. Given its potential to cause synaptic dysfunction, clostridium neurotoxin might play a role in the neurodegenerative process responsible for PD. If a Clostridium neurotoxin contributes to the pathogenesis of PD, an inverse correlation would be expected between the administration of the tetanus toxoid vaccine and the incidence of PD."
will STOP or SLOW parkinson's
