Diabetic drug could slow the progression of Parkinson’s disease

[Kia17]

“Effects of the alpha synuclein aggregates could be greatly reduced by the anti-diabetic drug glibenclamide.”

selectscience.net/industry-...

[Xenos]

"It is known that patients treated for type two diabetes have less prevalence of Parkinson’s disease."

Really ?

[Parkinsonjisung in reply to Xenos]

Yep.. theres lots of research on this. Here's one from last month: parkinsonsnewstoday.com/202...

[Kia17]

Do you have type 2 diabetes?

[pdkid]

hm, i wonder how accessible this drug is... and what it means to slow it down with it. interesting! thanks for sharing!

[Patrickk]

[cut-and-paste -- I drop this wherever it may be of interest ]

Bydureon, a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2023. Testing — mice, open label, double blind — has been going on for 10 years and it has been positive every time.

scienceofparkinsons.com/201...

According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to Bydureon.

scienceofparkinsons.com/201...

cureparkinsons.org.uk/news/...

[Hidden in reply to Patrickk]

I like your exenatide posts. Appreciate the positivity 👍

[Kia17 in reply to Hidden]

Thank you Chris.

[gl2238]

Only 10 years, sounds like big pharm is involved. I would appreciate a trial now. forget the mice.