Antibiotics and Madopar

[Grumpy77]

Do antibiotics disable the effectiveness of madopar? Since i started antibiotics a couple of days ago, I've been shakier, stiffer in neck and more anxious.

[Juliegrace]

I think it’s more likely that whatever infection you’re being treated for is the culprit.

[Carpediadem in reply to Juliegrace]

Doxycyclin

[Grumpy77 in reply to Carpediadem]

Please can you explain further , thank you

[Carpediadem in reply to Grumpy77]

Hi Ive have red about it in several artichles.. Google!

[Grumpy77 in reply to Carpediadem]

I can't see anything related to my question

[jeffreyn in reply to Grumpy77]

This won't help, but it might be of interest.

"Brazilian researchers discovered doxycycline’s ability to prevent Parkinson’s symptoms when mice were mistakenly fed chow containing the antibiotic."

healthunlocked.com/cure-par...

[Grumpy77 in reply to jeffreyn]

My apologies, you prob misunderstood my comment up there. My original ques wasn't abt Doxycycline.

I was just responding to the other person who wrote one word "Doxycylin" to explain further what they meant

[pdpatient]

I agree with Juliegrace . Recently, I was infected with covid and I was just miserable for two weeks. My MDS said that it was more than likely to be the result of covid.

[Gcf51]

I had the opposite reaction with C/L . After I had antibiotics to treat Sepsis, I went a couple of months with no symptoms.

[Grumpy77 in reply to Gcf51]

The positive impact needs to be investigated and the benefits ingredients isolated and extracted

[park_bear]

Antibiotics will change the composition of the gut microbiota for better or worse. This could affect Parkinson's as result of changes in production of short chain fatty acids and the microbiota's metabolism of levodopa

[Grumpy77 in reply to park_bear]

Hmm... means there's not much I can do about it, I'll just have to endure the worsening of my symptoms for the remaining 4 days left

Thank you park_bear, always very insightful

[pearlette]

Lot of reasons

1.

Most people who take antibiotics tend to get some degree of softening of bowel contents. This is because they tend to have sodium or other salt loads and bulking material to cause osmotic drag of fluid into the bowel cavity.

This means absorption gets affected

2. Then you have secondary causes; many affect renal and hepatic clearance of man drugs (this can make your kidney or liver clear whatever other drugs you take , some of which manage the Parkinsons

3. Eventually gut bacteria changes occur temporarily (some cause more prominent and longer term effects)

4.Different antibotics have other effects on gut motility independent of point 1.

Examples are :

Erythromycin , clarithromycin have direct action on cholinergic receptors (Acetylcholine neurotransmitter) causing increased gut motility speeding up the gut)

This neurotransmitter "counteracts" dopamine in realtime in some functions . Some of the characteristic features of Parkinsons are a direct result of this minute to minute imbalance of movement (rigidity, slowness and possibly coordination.

and finally take into account that all infections make you feel rotten in many ways.

[Grumpy77 in reply to pearlette]

Hmm, very complex interaction it seems, Thank you so much

[pearlette]

Yes allneurotransmitter interactions are cmplex.

The knowledge we have barely scratches the surface (sadly)

[upadasa]

I started with 4 tabs, per day but i reduced it to 3 with dopu mucuna tabs and it seems to work for me.