Madopar and HDT times

[Grumpy77]

Can I take HDT (500mg) at exactly the same time with my regular Madopar dose (100mg/25mg), without fear of interference which may result in the loss of effectiveness of both or either of them?

Also is it relevant if HDT is taken on an empty stomach?

[park_bear]

I take B1 and C / L at the same time and they work together fine. I also take with food, but that's just me.

[Grumpy77 in reply to park_bear]

Thank you so much, 👍🏽

[park_bear in reply to Grumpy77]

I take C/L ER, which is generic for Sinemet CR. Regarding food, according to the Sinemet CR label: dailymed.nlm.nih.gov/dailym... "The extent of availability and peak concentrations of levodopa after a single dose of SINEMET CR 50-200 increased by about 50% and 25%, respectively, when administered with food."

I do not have any rigorous protocol. I usually follow a dose with at least a snack, or a meal.

[Grumpy77 in reply to park_bear]

Thank you. I thought that ì had asked the question in a complicated way bcos I was using 'x' +/-. So i deleted the question aiming to recompose later. But since you've answered the questions adequately, I will re-paste the original question below .

Question to park_bear:

Hi PB, when you say 'I take with food', do you still leave a gap of +/- x mins to your mealtime? Where x can very low, I mean...

How low can x be?

Do you always eat light? ie do you never eat heavy?

Or do you have special diets that make your meds work with food?

I'm asking bcos my meds don't work with me if I eat +/-< aprox 60 mins meds time

[gomelgo]

HDT? I would so appreciate if folks would help my little hurt brain with an explanation of abbreviations.

[Grumpy77 in reply to gomelgo]

HDT (High Dose Thiamine) which is a form vitamin B1. In high dosage can serve as an effective therapy for parkinson's disease Search for "HDT vitamin b1" here on HU site and a lot informative links will pop up

[gomelgo in reply to Grumpy77]

Thank you. About a year ago I thought it was going to be my ticket. I read and researched and then tried it and gave up because my worst symptom is anxiety and I need calming remedies.

[chartist in reply to gomelgo]

You might consider this supplement for its calming and antianxiety effects:

amazon.com/Source-Naturals-...

A word of warning :

These aren't the largest pills I have ever taken, but they are easily the hardest pill for me to swallow that I have ever come across and it requires two pills per serving which I generally have to choke down. I've tried chewing them, but the Holy Basil flavor is fairly strong! If the holy basil flavor isn't off putting, then these are worthy of consideration.

I find these calming in a similar way as mentioned in the reviews, which I highly recommend that you read. I really like this ingredient combination. If you decide to test this product for your anxiety, please give me your feedback as I am sure others with anxiety will also be interested since anxiety is quite common in PwP.

Art

[gomelgo in reply to chartist]

Super appreciate this. I put it in my cart, and will order when I am done with my current magnesium, just received the new bottle. Will definitely let you know how it lands when it does. 🙏

[chartist in reply to gomelgo]

This explains it :

healthunlocked.com/cure-par...

Art

[Markbit]

Hi Grumpy, check my last post. Lots of answers about B1 there