Latest paper from Dr. Peter Tass

[CBailey11]

twitter.com/peter_tass/stat...

t.co/CckvyVSaWH

I'm trying to wrap my head around it. Does anyone understand this?

[Neurosmith]

I *think* the gist is that they're saying that 'shuffling' the vibration sequence is crucial to long-last desynchronization vs non-shuffling. At first I thought he was introducing something new with the shuffling but I think the shuffling is the randomization of vibration pattern that he has talked about in previous papers in 2017 and 2022.

But, I could be way off so hopefully smarter people than me in this forum will read the paper (it's essentially a 2 page abstract) and offer their interpretation.

[PWPInnovate898 in reply to Neurosmith]

I agree with your interpretation. It appears that randomization of the patterns is critical for long lasting therapeutic benefits. Note this paper refers to DBS based CR stimulation, not coordinated reset stimulation delivered via the vibrotactile gloves. I also have a feeling that as these researchers discover the powerful waveform generation capabilities of the newer electronics, these new stimulation patterns become the focus of new studies.

Assuming these improvements can be applied to VCR, shuffling stimulation patterns is a relatively straightforward exercise for the software and electronics many DIYs are using to build VCR prototype gloves.

[Ethin in reply to Neurosmith]

No claim on being smarter, but I essentially agree with the interpretation: it's just an abstract and perhaps a preview of a longer upcoming theoretical study on the shuffling of DBS stimulation sequences in homogeneous (unrealistic) and inhomogeneous (more realistic) networks. I don't think the findings have any immediate consequences for the vCR therapy approach.

[Glovemaker in reply to Neurosmith]

Here's a link to my DIY glove project.

drive.google.com/drive/fold...

See the description of the algorithms I wrote. (The only thing missing from the description of the algorithms is Figure 1, which nevertheless appears in the Tass paper.)

It was difficult to write the description of the algorithms, because I was almost unable to write a sentence at the time, and I was profoundly depressed as well.

I built the gloves. My brother in law built the "box". My nephews wrote the software and the computer interface. All this took 4 months.

The gloves do work for me. Most of my mental symptoms cleared up rapidly after I started using the gloves last April (4 hours/day initially and now 2 hours every other day). I alternate among the algorithms. My neurologist noted improvement in several neurological tests and in my mental status. Sadly, I did not experience significant improvement in my gait/balance. But it's certainly worth it to have my mind in much better shape.

[WinnieThePoo]

It's not a lightweight is it?

[CBailey11]

The one thing that always seemed important to CR is the randomness. Random patterns, random jitter. He seemingly shared this out of the blue, indicating it might be something new. Maybe this was simply posted to back up his existing work? All I know is the more I read, the more my brain hurt. Maybe the document itself is supposed to do something?

[PWPInnovate898]

randomness does seem to be the theme in the more recent papers to produce long lasting benefits. Random patterns, random jitter, random amplitude, and even random frequency. All of these random variables appear to me to contribute to de-synchronizing the brain. And yes, my brain hurt, too reading this paper.

[CBailey11 in reply to PWPInnovate898]

I'm finishing up the menu to my FreedomWave, looking for features to add. Random amplitude and frequency sound interesting.

[BBTKD]

Where PD is concerned, to move the network into a less synchronized state is desirable as the pathological hyper-synchronized beta oscillations are thought to underlie the disorder. Also, DBS (deep brain stimulation) can override/reset the hyper-synchronized beta oscillations, but as soon as the battery is turned off, so is the effect. Here, they are saying shuffling can increase how long post-stimulation (CRS) amelioration of symptoms. They are also saying that the CR sequence is also relevant. In other words, like most things, timing is everything!

Here's the paragraph that tells you all you need to know, "we computationally analyse why shuffling may improve long-lasting effects of CRS. We uncover that the effect of nonshuffled

CRS depends on the selected CR sequence: “Favourable” CR sequences may drive the network into a WCDS; conversely, “unfavourable” sequences may induce an SCSS (Fig. 1B). We show that long lasting aftereffects of CRS with long shuffle periods depend on the timing at which stimulation is turned off, whereas short shuffle periods led to consistent long-lasting effects after sufficient stimulation duration"

CR- Coordinated reset

CRS - Coordinated reset stimulation

WCDS - Weakly connected synchronized states

SCSS - Strongly connected synchronized states