Another New And Completed FMT Study In 54 PwP Showing Clearly Positive Results Using Freeze Dried Oral FMT

[chartist]

Although this is not the Helsinki study results I was waiting for, this is a slightly larger size RCT study using freeze dried oral FMT capsules in PwP during the 12 week study. The results are positive in terms of symptom improvements and gut microbiome perturbance reductions. Here is a link to the full study :

tandfonline.com/doi/full/10...

Here is a relevant quote from the study :

' In the present work, we carried out an RCT study on the effects of FMT on patients with PD. We used freeze-dried fecal microbiota powder capsules, this preparation is much more acceptable and accessible for patients than conventional endoscopic routes such as colonoscopy or gastrointestinal tube, which require advanced endoscopists or radiological equipment, capsule preparation allows patients get FMT at home or through distant delivery. Herein, we demonstrated that oral FMT significantly improved the effect of conventional PD medications on PD-associated symptoms. Before the intervention started, participants in FMT and placebo group demonstrated similar clinical characteristics regarding the evaluation for PD, at the end of this trial, FMT participants demonstrated a significantly greater change in MDS-UPDRS total score, showing that PD symptoms were alleviated. '

' Specifically, compared with the placebo arm, the FMT arm had a more significant decrease in MDS-UPDRS part 1 score at week 4 and week 12, showing that patients had a significantly better quality of life. '

It seems like MJFF should fund an FMT/PD of an even more robust nature since they are in the business of funding relevant and important PD related studies. How many more years of being in business will it take MJFF to do this?

Art

[binnyrox]

Hello again Art!

Thanks much for an excellent post

Fully agree with your note regarding a MJFF study - D has experienced some benefits whilst on FMT

You’re probably aware of this recently FDA approved FMT pill fda.gov/news-events/press-a...

All best for the season

d&ww

[gaga1958 in reply to binnyrox]

Unfortunately that approval is only for 1 specific diagnosis

[binnyrox in reply to gaga1958]

The FMT my husband had was the to treat C. difficile. I read PD Tom’s post below and his FMT formula seem the similar off-label formula

I could be mistaken but it appears the FMT formula given in the trials for Parkinson’s are the same as the ones to treat C. difficile

But yes you are right - it is approved for 1 specific diagnosis and apparently, very successfully

Glad you pointed it out and hope it clarifies in some way

[PDTom]

I already had two....

parkinsonclub.de/en/microbi...

parkinsonclub.de/en/microbi...

[Bolt_Upright in reply to PDTom]

How are you doing Tom? Holding steady (or better!) I hope.

[PDTom in reply to Bolt_Upright]

Thank you for asking. I'm doing very well. My symptoms fluctuate a little but on the whole they are very stable. Enclosed is an overview of my evaluation. I think I can maintain this level for a long time to come. I hope that "Buntanetap" will come onto the market in 2025 and help us! On 15 December, the three years since my diagnosis will be over.... Time is running out!

3.12.2023 www.parkinsonclub.de/en

[Bolt_Upright in reply to PDTom]

That's great! It looks like you are holding steady and/or improving!

[LeharLover62 in reply to PDTom]

Wonderful! How did you find clinics to do this?