Stem Cells for PD - To wait or not to wait? - Cure Parkinson's

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Stem Cells for PD - To wait or not to wait?

Alock2020 profile image
9 Replies

It's my understanding that while the research looks promising, there might not be FDA approval for at least another 5 or 10 years.

However, I've noticed that there are a number of clinics offering stem cell transplants for anywhere between $5,000 to $50,000. Perhaps in a year or two, a few of these clinics might be well rated in terms of their success, while those that kill many of their patients won't be.

Does it make sense to get the procedure done by someone competent before it's approved? Some people can't afford to wait 5+ years.

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Alock2020 profile image
Alock2020
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9 Replies
jeffreyn profile image
jeffreyn

In regard to mesenchymal stem cells (MSCs), the researchers don't yet know how many doses are appropriate, the appropriate amount of time between doses, and the appropriate size of each dose.

park_bear profile image
park_bear

No, because a reliable measurement of success requires a properly run clinical trial. Among other things such trials are registered at the clinical trials website, and reported on in peer reviewed medical journals. None of these "clinics" offering stem cell treatments meet this standard. Self-reported testimonials don't cut it because you can bet they're not going to list negative experiences.

For low risk interventions such as nutritional substances, these requirements can be relaxed because they are in common use. On the other hand there are cases of stem cell treatments going seriously wrong.

Boscoejean profile image
Boscoejean in reply topark_bear

This is not to discount the benefits of nutritional substances.

Hope Biosciences clinical trials are approved by the FDA

classic.clinicaltrials.gov/...

classic.clinicaltrials.gov/...

even though this trial is no longer available it was approved by the FDA

classic.clinicaltrials.gov/...

gaga1958 profile image
gaga1958 in reply toBoscoejean

Did they report results?

Boscoejean profile image
Boscoejean in reply togaga1958

I am hoping the information about the trial that involved 75-95 year olds will be available in the near future

jeffreyn profile image
jeffreyn in reply togaga1958

Hope Biosciences has recently published some results from their "MSCs for PD" research.

healthunlocked.com/cure-par...

Michel0220 profile image
Michel0220

I understand the temptation but I think it is too early as clinical trials are still ongoing.

pdpatient profile image
pdpatient

You have hinted at the hobson's choice yourself. Go for it now and maybe get cured or perhaps die at the table or suffer through the next 5 to 10 years and then go for the truly good thing 😅

I made my choice right there. 😜

Baron1 profile image
Baron1

Good Morning,

This a copy of my reply to a similar question asked one month ago.

This is a very controversial topic. Everyone has their opinion and beliefs of what, or if stem cells can help with neurological disorders.

Yes there are clinics everywhere spruiking that stem cells have helped their patients, but as I once posted here before, there are literally one million plus people just in the USA with some form of a neurological disorder. So why are there not more positive success stories in the media?

Anyway, I am inclined to be a believer that they do work, to some degree but there is a caveat as well. What type of stem cells?, and then there is also the question are they from a donor, MSC's, placenta, fetal, etc, etc, etc.

Intraveously administered or intranasal? Intranasal is showing some promise as being more beneficial by upstreaming via the olfactory bulb. The intranasal route allows for direct access to the central nervous system without crossing the blood–brain barrier, avoiding potential adverse reactions and enabling the administration of large quantities of stem cells to reach the brain.

Then there is the one question that many clinics do not explain and show the screening results, what are the stem cell sizes that they use.

If they are too big, they will end up being trapped in the filter organs, like the lungs, and spleen. When this happens research studies show that it can cause issues and subsequently the stem cells that get through to the hippocampus are limited in number, and that is why majority of people never see a benefit or only a small improvement which does not last long.

Studies have shown that those who had several intravenous doses over the course of several months had the highest percentage of change from baseline in improvements based on the studies parameters, and the improvements lasted after 24 months follow up.

I recall Jack Nicklaus has had stem cell treatment at Isar Klinikum in Munich, Germany, in 2016. So he is no fool, and he stated that it helped him for his back issues that surgery and medicine could not fix.

edition.cnn.com/2018/04/27/...

There is CellTex Houston Texas, and they administer by intravenously and intranasal. Success rate I am not sure, you may have to do some further research.

I am in Australia, so I am looking as well, but I am yet to find one place that has all boxes ticked in my opinion. They charge alot, and that is why you most first be convinced that they have a track record of success with patients and not just emptying your bank account.

Here are some links that you may want to read about Stem Cells.

statnews.com/2020/08/18/sep...

aarp.org/health/conditions-...

Best of luck and lets us know if you find anything worthy of looking into.

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