Thiamine interaction with olanzapine ?

[TL500]

Hi all, sorry if I have posted this question before, could anyone give me your opinion/ knowledge/ experience on this please.Thanks very much

ehealthme.com/drug-interact...

[chartist]

They list two interactions between thiamine and olanzapine, but when you click on either one, it gives the following message :

' Sorry, the report you requested is not available. '

When you look for interactions between thiamine and olanzapine on drugs.com, they show none :

drugs.com/interactions-chec...

Dr Costantini said that he had never seen interactions between thiamine and any medications used for PD.

What is your concern about these two?

Art

[TL500 in reply to chartist]

Thanks very much Art for your quick response. I appreciate it. Because I see that Thiamine helps so many conditions so I decided to give Thiamine 50mg to 100mg to my young person who has cerebral palsy and from 2020 diagnosed with psychosis, schizophrenia. She is taking up to 10mg Olanzapine. My concerns is will Thiamine interact with Olanzapine and cause "neuroleptic malignant syndrome among females " like what they say here.I used to give her it a short period of time, while also giving PS128, and that time she also had Quetiapine 25mg and Olanzapine 5mg, one day in the airport and on the plane she started to selftalk more and laughed all the way uncontrollably. Since then she sometimes laughed uncontrollably, now is not that often and not that much. After I saw this article, I don't know if it is what it was about.

Please tell me what you think. Thanks

[chartist in reply to TL500]

Vitamin B1 and B12 are suggested to have some benefit for cerebral palsy (CP), but you would have to check with your doctor to find out if it is compatible with all of the prescription meds she is taking. You might also ask her doctor about these other two also.

The following study discusses the potential benefit of B1 and B12 for CP :

ncbi.nlm.nih.gov/pmc/articl...

Here is a relevant study quote :

' Collectively, vitamin B1 and B12 up-regulates BDNF and its downstream PI3K/Akt signaling through MALAT1/miR-1 axis, thus suppressing neuron apoptosis and mitigating nerve injury in cerebral palsy rats. '

Also related to CP, vitamin d deficiency is common and should be corrected :

ncbi.nlm.nih.gov/pmc/articl....

A relevant quote from the study :

' Patients with CP are at an increased risk of vitamin D deficiency and as a result reduced bone mineral density, bone fragility, osteopenia, and rickets. '

Magnesium Sulfate has shown benefit in people with CP as discussed here :

flintrehab.com/vitamins-for....

A relevant article quote :

' Over 75% of individuals with cerebral palsy experience spasticity (involuntary muscle contractions), making it difficult to move and eat effectively because their muscles continuously contract. Magnesium may reduce spasticity and increase range of motion by relaxing the muscles and promoting nerve function. '

Art

[TL500 in reply to chartist]

Thanks very much Art for your information. It always helpful. I appreciate it.I haven't asked her doctor, but I brought it up with his assistant who is a nurse and she seemed didn't think so (or didn't know about this). I rang and asked the chemist where we buy the prescription, they searched on their computer and told me that Thiamine doesn't interact with Olanzapine.

In your opinion, Do you think the article is genuine?

[chartist]

Honestly I run into these ehealthme articles pretty regularly and based on what I've read to date, I generally ignore them now because like I said, they mentioned two interactions and when I clicked the links they both said it could not be found. How am I going to base a health decision on that kind of information?

One other thing you can try is to contact the manufacturer of the drug and ask them. It seems like if anyone would know, they would.

Art

[TL500 in reply to chartist]

That's a good idea.Thanks Art.

[LeharLover62]

if they already have psychosis or hallucinations prior to high dose thiamine…personally, I would be cautious. These are different medical conditions so it’s hard to know or compare, but hubby has advanced PD with hallucinations, and many different meds can make it worse including High dose thiamine.

My theory is that he is hyper sensitive to anything that raises dopamine levels natural, supplement, or medication and this acts on the receptors to cause psychosis.

He hasn’t yet tried any antipsychotics so we don’t have experience with opanxapine. But if it were him, I would make very small very slow changes to any medication or supplement and closely monitor symptoms. So maybe slowly stop the thiamine, wait 2-3 weeks and document changes.

[TL500 in reply to LeharLover62]

Thanks. They say that psychosis is because the person has too much or hgh level (?) of dopamine, that's why I wasn't sure whether 100mg Thiamine or 1x PS128 raise level of dopamine.. and or like the above link says about Thiamine interaction with olanzapine.

[LeharLover62 in reply to TL500]

Again, everyone is different, for him probiotics do not seem to cause psychosis…but the thiamine can. But it may be that she can still tolerate the thiamine, but maybe needs a break from it or a lower dose.

I’m assuming you have a way of tracking meds and symptoms? When the hallucinations started, it became very important, so I keep a detailed log each day which includes dosages, times, and symptoms including hallucinations, anxiety, confusion, etc. If a new round of hallucinations start, I then look back through this log to get ideas for what the trigger might be. It might be stress, lack of sleep, exercise (or most likely )supplements and medication changes.

[TL500 in reply to LeharLover62]

Thanks for the idea. Your husband is lucky to have you taking so good care for him and thorough.Has he tried PS128?