THIAMINE

[ecurb]

I have today noticed many questions concerning use of this vitamin to help alleviate and even reverse parkinson's symptoms with a high success rate it would seem. However it seems also that this vitamin is mainly rejuvenating whatever substantia nigra cells have survived since the beginning of cellular loss . That could mean that people having lost a great number of these cells over the years could only expect a minor success if any from thiamine.

[Xenos]

You mean that thiamine only stops PD ?

How disappointing ...

[bassofspades]

according to Dr Costantini, Theraputic Thiamine produces complete remission within 2 months. I am on week number 3 so I'll keep you posted. I will report my results or lack thereof April 1st.

[Hidden in reply to bassofspades]

according to Dr Costantini, complete remission? I don't recall that. I do recall great improvement in PD test scores. I am into by five weeks and based on my condition I choose to continue.

[bassofspades in reply to Hidden]

I recall reading that in an interview. I will try to relocate the source. I wouldnt just throw that up there willy nilly!

[bassofspades in reply to Hidden]

Im having trouble finding those exact words so I must retract my misleading statement. So sorry. I swear I thought I read that as a quote from the good DR!

[Hidden in reply to bassofspades]

1.

A research has confirmed the results obtained in Italy by Professor Antonio Costantini regarding the use of Thiamine to fight Parkinson’s disease. The National Center for Biotechnology Information of the United States have published the study on their website. The program followed 50 patients which have been treated since June 2012.

Ultima Edizione has dedicated a section to Costantini’s studies on Parkinson’s.

The research concerned 33 men and 17 women aged between 70 and 13 years old, which have suffered from this disease for an average of 7.3 and 6.7 years. All of the patients began their treatment with an intramuscular injection of 100mg of Thiamine twice a week, without any personal variation. Every patient was reevaluated after a month and underwent controls every three months during the treatment.

According to the researchers, treating patients with Thiamine has led to a significant improvement in the motor and non motor symptoms within three months and has remained stable after time. Some patients of a condition of medium to bad severity have seen a complete regression of the symptoms. The period of observation varied between 95 and 831 days, with an average length of 291 and 207 days.

The conclusions drawn by the Italian researchers, among which doctor Roberto Fancellu, are that the parenteral administration of high doses of Thiamine has proven effective in countering Parkinson’s motor and non motor symptoms. Every patient’s improvement has remained stable throughout time.

“From our clinical evidence, written in the research, we hypothesize that a dysfunction in the thiamine-dependant metabolic processes could cause selective neuronal damage in areas commonly affected by this illness and could be a fundamental molecular event causing neurodegeneration. Thiamine could have a restorative and protective effect against Parkinson’s disease”.

ultimaedizione.eu/usa-news-...

2.

The treatment with thiamine led to a significant improvement of PD symptoms: UPDRS part II improved from 12.5 ± 4.0 to 7.7 ± 3.5 (P < 0.001, t-test for paired data), motor UPDRS part III improved from 21.6 ± 4.8 to 11.8 ± 6.0 (P < 0.00001, t-test for paired data). The Hoehn and Yahr score (UPDRS part V), a disease stage measure, significantly improved from 3.0 ± 0.8 to 2.5 ± 0.6 (P < 0.001, t-test for paired data); also the Schwab and England functional score (UPDRS part VI) significantly improved from 69.0 ± 18.5 to 80.0 ± 12.5 (P < 0.05, t-test for paired data). The clinical motor improvement was even higher during the second month of treatment, after the increase of the dosage of thiamine associated with the increase of levodopa for the patients already in treatment with this drug, or after the beginning of the treatment with levodopa for the patients naïve for this therapy. The mean daily levodopa dose after two months was 515.0 ± 228.6 mg. Some patients with a milder phenotype had a complete clinical recovery. No patient experienced adverse events or discontinued the treatment.

ncbi.nlm.nih.gov/pmc/articl...

3. (other notes indicate the occasion of lower dose. Here, higher dose)

A fixed dose of Thiamine, in addition to the old therapies, provides even more positive results for the patients. If we deem the improvements to be insufficient we can alter both the old treatment and the dosage of Thiamine, in order to unburden patients from every symptom or provide a considerable improvement compared to the previous treatment.

Q: So the administration of the vitamin B1 to patients suffering from Parkinson is compatible with the other cures currently adepte by Italian hospitals?

Yes, it’s compatible with every therapy. Not just with the medicines used to fight Parkinson, but also with any other substance in the pharmaceutical handbook. It’s important to add that the old therapies do provide some degree of improvement. A fixed dose of Thiamine, in addition to the old therapies, provides even more positive results for the patients. If we deem the improvements to be insufficient we can alter both the old treatment and the dosage of Thiamine, in order to unburden patients from every symptom or provide a considerable improvement compared to the previous treatment.

Q: Given the delicacy of the matter, and to avoid giving false hopes to the ill, can you confirm, after five years of administrating massive doses of Thiamine, that this treatment truly benefits patients?

Yes. It’s confirmed. We even invite many patients to keep us updated with yearly phone calls because they no longer need rigid neurological control.

Q: Besides Thiamine, what other pharmaceuticals are needed to contrast the disease?

There’s the classic medicines, like levodopa, which causes no harm whatsoever to the patient on the long run. There are also other compounds that are normally used in Parkinson like the dopamine agonist and other stronger drugs that have recently been made available. I would like to precise, however, that these are all pharmaceuticals that simply stop the symptoms but are unable to stop the progression of the disease. Thiamine can stop it.

Q: Currently, are Italian hospitals equipped towards the cure for Parkinson?

They are very well equipped, but even if the patients are followed diligently by neurologists, the possibility of a successful treatment through the use of these drugs only is rather slim. The patients can’t always reach the results achieved with the Thiamine, which stops the progression of the disease

and at the same time greatly alleviates the symptoms.

ultimaedizione.eu/parkinson...

[bassofspades in reply to Hidden]

Thank you again Roy the quote was Some patients of a condition of medium to bad severity have seen a complete regression of the symptoms

[MBAnderson in reply to Hidden]

Are you taking it as an injection?

[Hidden in reply to MBAnderson]

Please recall my earlier Posts and Replies. Oral. My first good results were the result of 500mg Mega-Benfotiamine per day. I discovered better results through 2g at 4am then 2g at 4pm of Thiamin HCL, orally.

[MBAnderson in reply to Hidden]

Thank you, thank you. I should've known to go back and read your earlier post. Yeah

[KERRINGTON in reply to Hidden]

Yes, thank you too for all your info on thiamine. I'm always referring back to your posts. It has really made a difference in how I feel. I also notice working my arms on a rowing machine has helped a lot to quell right shoulder stiffness/shakiness.

[Jmwg45 in reply to Hidden]

Hi RoyProp.

Is there a reason for your 4am/4pm timings?

I’m doing 2g at both 10am/10pm because it’s convenient but largely took the plunge after seeing your posts (after much further research).

So far, 5 weeks in it’s the best thing I’ve done.

[Hidden in reply to Jmwg45]

It fit my activity. Originally to keep meals and C/L dose separate. Now I read group member posting that separating by hours is not necessary with controlled release med.

[Erniediaz1018 in reply to Hidden]

Thanks Royprop. Where did you purchase from.

[Hidden in reply to Erniediaz1018]

Solgar Thiamin HCL 500mg from Amazon or special order from lifeextension.com

You will need to order several bottles to get you by for several weeks at 8 tablets a day

and the shipping delay.

[Erniediaz1018 in reply to Hidden]

Thanks again friend.

[Greenday in reply to Hidden]

In Europe, I can only find the 500mg Solgar thiamine in Tablets. Unfortunately It is not available in 500mg Capsules from Solgar. Those with swallowing problems may find more convenient to open and pour the powder contained in the capsules in a glass of juice. Any alternative is appreciated.

[Jmwg45 in reply to Greenday]

In uk I couldn’t find anyone with Solgar in stock so used G&G Vitamins 500mg Thiamine HCL from Amazon (£18.68). I’m on prime so no delivery charge and have been able to order for next day delivery. Working for me

[Greenday in reply to Jmwg45]

Thank you for your reply. I'm only able to find G&G too in Europe. I don't know how it compares to Solgar's, but lack of alternatives.... Good to know that it works for you.

[Jmwg45 in reply to Greenday]

I was keen to get the Solgar and had ordered it from Revital who shipped 100mg. I returned and they then informed me that even Solgar had no stock.

Tried G&G as all I could get. I am, 5 weeks in, seeing a big benefit from it on all aspects of my condition - physical and mental fatigue, anxiety, better focus, clearer thoughts, clearer and louder speech, less dragging my leg, happier.

Still early days though so I’m seeing this as a reprieve for the moment with no expectations of it lasting but boy have I got my fingers crossed.

I’ll try and I pdate my profile later about me for completeness

[Greenday in reply to Jmwg45]

Did you experience any reduction of tremors, rigidity or pain?

I currently take Sulbutiamine for fatigue (already 2 weeks), I'll try the G&G Thiamine after a month since you buck up its efficacy. I'll definitely keep an eye on your profile updates.

[Jmwg45 in reply to Greenday]

I'm lucky enough not to suffer tremors except when extremely stressed (non tremor dominant). I am less rigid though and looser throughout my body (except for lower back pain I've had about 4 months - I suspect this one isn't PD).

Also - I have for years had calf cramps in the night and upon waking almost daily - none now for 3 weeks. I would definitely recommend and hope that your experience is as positive as mine and that mine isn't simply a false dawn. I also take B1 complex (100mg) - 1 daily for the B6 mostly (I use the Solgar one) and Magnesium Citrate (helps B1 absorption apparently).

Remember, I didn't feel any benefit for about 2-3 weeks then it kicked in one weekend, then seems to be gradually improving further.

[Parkie- in reply to Jmwg45]

Hello Jmwg45.

I am thinking of trying Thiamine. I just read your post

''I'm lucky enough not to suffer tremors except when extremely stressed (non tremor dominant)....''

I have similar symptoms (non-tr dominant, dragging one leg). I am wondering how you are doing since your post. Thiamin still beneficial? any adverse effects? Many Thanks.

[DennyW in reply to Jmwg45]

Jmwg45 - like you, I am also not tremor dominant except when under extreme stress. And I've got the low back pain, which so far (3 weeks in) the thiamine isn't improving. But I have had good gains in energy and my gait is more fluid. One note: be cautious with taking B6. Even 50mg a day is way too much. It's the one b vitamin that definitely can build up and become toxic. Signs of B6 toxicity are often neurological and difficult to distinguish from B12 deficiency. I take a b complex without B6 and add my own liquid B6, just three drops per day, for a low dose. I also take a B6 holiday once or twice a week.

[Erniediaz1018 in reply to Hidden]

Sorry to bug you with this but I’m very interested in getting the right product .. is this it amazon.com/Solgar-Vitamin-T...

Just concerned it doesn’t say hcl

[Hidden in reply to Erniediaz1018]

I clicked the picture, rotated the bottle, and yes its hcl

[Farooqji]

You mean that using thiamine in early stages is more beneficial? Are you concluding this on the basis of some study?

[Hidden in reply to Farooqji]

according to Dr Costantini, less effective if you had PD for 20-30 years

[jeeves19 in reply to Hidden]

Once begun does the protocol need constant application? I.e forever?!

[Hidden in reply to jeeves19]

PD is forever

[Farooqji]

OK , thanks

[Jmwg45]

I’m about 5 weeks in on 2x2g per day and whilst no complete remission I have much less fatigue (physical and mental) in the last 2 weeks. I can focus better and also function better physically.

It’s early days so I won’t get carried away but I am very pleased I started. Thanks to RoyProp for his posts and insight which inspired me to get started about the time he did with thiamine HCL.

[Fava-1]

I have had considerable improvement just adding nuts to my diet, so I am sure a lot of us have thiamine deficiency. Whatever the reason....I keep eating the nuts! It has been over a year now and my mandolin playing is still improving

[laglag in reply to Fava-1]

What kinds of nuts? For about 5 or 6 mths i've been eating a bowl of Cherrios with blueberries & almond/coconut milk for breakfast & throughout the day about 3 handfuls of almonds, Brazilian nuts, walnuts, pumpkin & sunflower seeds with raisins & dried cherries & bits of dark chocolate & it's improved my constipation 95%.

[John112233 in reply to laglag]

I'm not the OP but I eat a cup of mixed nuts most days. They are high in b vitamins, and minerals

nutritiondata.self.com/fact...

They sell mixed nut bags at supermarkets in Australia. Rice bran cereal is also high in b vits.

[Fava-1 in reply to laglag]

1 brazil , a couple handfuls of cashews, 2 apricot kernals ,5 almonds, a couple handfuls of pistachios in the shell, and walnuts in my gluten free cookie concoctions.

[laglag in reply to Fava-1]

Yum. I also have cashews in my mix.