People with PD are at increased risk for getting UTIs and the symptoms can often be significantly worse in PwP according to this April 2022 article :
ncbi.nlm.nih.gov/pmc/articl....
Here are two very relevant quotes from the article :
' UTI is a leading cause of acute hospitalization in patients with PD [8, 9]. Even when not the primary cause for admission, UTIs are often found incidentally at higher rates in patients with PD compared to the general population [10]. Patients with PD who undergo surgeries, both elective and emergency, are also known to be at higher risk of UTI [11]. In one review of nine retrospective studies of 433 patients with PD, UTI was reported to be one of the most frequent orthopedic postoperative complications, in frequencies up to 49% [12]. The risk of UTI is elevated in patients with PD following total hip arthroplasty (OR = 1.39; 95% CI, 1.09–1.76; p = 0.007) [11, 13], while one-third of patients with PD develop UTI after total knee arthroplasty [13, 14]. These studies highlight the particular risk PD patients undertake when undergoing operative admissions. As UTI-induced motoric dysfunction in PD likely contributes to an increased risk of falls [15] and PD-associated bladder dysfunction increases the risk of UTI, future studies are necessary to clarify the exact directionality of the relationship between UTI and orthopedic injury. '
' Urinary tract infection (UTI) is a common precipitant of acute neurological deterioration in patients with Parkinson’s disease (PD) and a leading cause of delirium, functional decline, falls, and hospitalization. Various clinical features of PD including autonomic dysfunction and altered urodynamics, frailty and cognitive impairment, and the need for bladder catheterization contribute to an increased risk of UTI. Sepsis due to UTI is a feared consequence of untreated or undertreated UTI and a leading cause of morbidity in PD. Emerging research suggests that immune-mediated brain injury may underlie the pathogenesis of UTI-induced deterioration of PD symptoms. '
Standard medical treatment for UTIs involve the use of highly potent antibiotics such as Ciprofloxacin. Unfortunately potential side effects from cipro and other highly potent antibiotics used for this purpose can be severe and many as discussed here :
drugs.com/ciprofloxacin.htm...
Here are some of the side effects listed in the above link :
Stop taking this medicine and call your doctor at once if you have:
low blood sugar - headache, hunger, irritability, dizziness, nausea, fast heart rate, or feeling shaky;
nerve damage symptoms - numbness, tingling, burning pain in your hands, arms, legs, or feet:
serious mood or behavior changes - nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or
signs of tendon rupture - sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).
In rare cases, ciprofloxacin may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.
Also, stop using this medicine and call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
any skin rash, no matter how mild;
muscle weakness, breathing problems;
little or no urination;
jaundice (yellowing of the skin or eyes); or
increased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea,
vision problems, pain behind your eyes.
Common ciprofloxacin side effects may include:
nausea, vomiting, diarrhea, stomach pain;
headache; or
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Ciprofloxacin side effects (more detail)
Since standard antibiotics can sometimes cause significant side effects, I would like to try and avoid side effects if at all possible. I make a drink at home that I have found useful for the purpose in my family and myself and I will describe how I make it below.
A WORD OF WARNING :
I am only describing what I make for my family and myself, but can not recommend this for anyone else because it is not tested or approved for UTI treatment and if anyone decides they want to try it, they should absolutely consult their doctor or professional medical care provider first and get their doctor's approval and supervision before making and using this mix. I am just giving an anecdotal report of my experience and I am not a doctor so I can not give medical advice. UTIs can be serious health issues, especially in people with PD, so having your doctors approval and supervision is imperative. Perhaps your doctor will allow the use of this drink in combination with their planned treatment.
What I Make
A potent antimicrobial that can fight UTIs is Grapefruit Seed Extract (GSE), not to be confused with Grape Seed Proanthocyanidin Extract (GSPE). This is available as a liquid concentrate. For an active UTI, I make a mixture of a few ingredients in a 500 ml bottle of filtered drinking water :
1- 500 ml bottle of filtered drinking water and pour out or drink one to two ounces to make room for the other ingredients.
10 - drops of GSE liquid concentrate. GSE is a broad spectrum antimicrobial with a very good safety profile.
pubmed.ncbi.nlm.nih.gov/158...
A relevant study quote :
' These preliminary data thus suggest an antibacterial characteristic of dried or fresh grapefruit seeds (C. paradisi) when taken at a dosage of 5 to 6 seeds every 8 hours, that is comparable to that of proven antibacterial drugs.'
The following study suggests the effectiveness of GSE for this purpose :
ncbi.nlm.nih.gov/pmc/articl...
A relevant quote from the review :
' Despite the limitations of the studies, the consistent results observed among all studies give support to the general findings that D-mannose may be useful in the treatment of UTI/cystitis symptoms. '
The Four Ingredients
1 - level half teaspoon of sea salt. I use pink sea salt, but other types of sea salt should work. It acts as an antibacterial.
1 1/2 - level teaspoons of D-Mannose powder added to the bottle of water. The powder avoids me having to swallow capsules. D-Mannose is the active component in cranberry juice.
10 Drops grapefruit seed extract
500 ml bottle of filtered water
Using a smaller funnel I add the three ingredients to the bottle of water and shake until all is dissolved and I drink the bottle within an hour. I make and take 2 or 3 of these bottles per day and continue for a day or two after symptoms are gone. Usually, the first day I take 3 bottles and see how I am feeling. If I notice improvement, I will go down to 2 bottles per day. I start this drink at the first hint or sign of a UTI, before it is raging. It is my experience, that when I start at the first indication of a UTI, the drink has been very effective for me and I have not noticed any side effects in myself.
The D-Mannose binds to E. coli and prevents it from attaching to the urinary tract surfaces allowing the bacteria to be flushed from the urinary tract when I urinate. E coli accounts for the majority (about 90%) of UTIs.
ucsfhealth.org/conditions/u....
A relevant quote :
' The most common bacteria found to cause UTIs is Escherichia coli (E. coli). Other bacteria can cause UTI, but E. coli is the culprit about 90 percent of the time. '
On a related note, Grape Seed Proanthocyanidin Extract (GSPE), not to be confused with GSE, can act as a preventative against UTI caused by Enterococcus faecalis and it has a very good safety profile as well as a multitude of health benefits. Here is a link to a product I use at the label recommended dose of 1200 mg (3 capsules) :
amazon.com/Carlyle-Grape-Ex...
Here are links to some of these products to give you an idea of what to look for :
D-Mannose Powder:
amazon.com/s?k=d+mannose+po...
Pink Himalayan Sea Salt :
amazon.com/s?k=pink+sea+sal...
GSE Liquid Concentrate :
amazon.com/Nutribiotic-Liqu...
amazon.com/Nutribiotic-Liqu...
Art
Dihexa peptide shows potential for PD and ALZ and (I believe) is currently available 
Patients with Parkinson’s disease (PD) report a strong craving for sweets
I'm seriously considering the carnivore diet. 6 anecdotes.
