Resveratrol, Vitamin E, Metformin Damage

[JayPwP]

Not specific to PD, but what is your opinion on this?

youtu.be/KS48ZgYGZbE(Not working as expected?)

[MBAnderson]

Good find Jay

bye - bye Resveratrol

youtube.com/watch?v=JAFnD27...(Not working as expected?)

ncbi.nlm.nih.gov/pmc/articl...

So much for Dr. David Sinclair

[chartist in reply to MBAnderson]

I completely agree with his message. When I tested resveratrol from low dose to very high dose, I saw zero benefit. When I read studies about resveratrol, they never popped out to me as being highly effective, more lackluster imo. I never really understood why resveratrol had so much hype around it, because the studies didn't seem to support the hype.

If I wanted to activate Sirt1, I would just take melatonin, astaxanthin and or berberine, of which I take all three, but it is not for life extension. They all have good studies to support their benefits.

Art

[park_bear]

Interesting. No idea on metformin and resveratrol. I did look at vitamin E - the results are mixed. Not convinced it is harmful but not convinced it is beneficial either. He flashed a study showing increased risk of prostate cancer of 1.17. Not enough to take note of in my opinion. There is an interventional study of folate supplementation at ordinary levels that showed increased risk of prostate cancer by a factor of 2.4 - now that is the kind of number a person should really take notice of.

Bottom line - he has a valid point about vitamin E and probably for the others too, but folate supplementation is a much bigger issue.

[Sydney75 in reply to park_bear]

Resveratrol is very poorly absorbed, needs to be micronized. I have read more positive than negative. I guess best method is via foods high in resveratrol rather than a supplement.

[JayPwP in reply to park_bear]

Folate singularly or as part of a B-complex?

Vitamin E increasing prostate cancer risk had first come to my attention around 12 years ago.

Also the MIND diet authors found no benefit of vitamin E supplements which are Alpha tocopherols or something like that

[park_bear in reply to JayPwP]

Folate - either way. See my writing here, including references to studies:

Folate Supplementation Carcinogenic tinyurl.com/ycdrz5lj

[JayPwP in reply to park_bear]

Are there any B-complex without folate? What about B12? Do you recommend such supplementation?

[chartist in reply to JayPwP]

People with PD generally have lower B12 levels and higher homocysteine levels.

ucsf.edu/news/2018/03/40999....

ncbi.nlm.nih.gov/pmc/articl....

B12 can lower homocysteine.

ncbi.nlm.nih.gov/pmc/articl....

High homocysteine is thought to drive PD development and disease progression.

onlinelibrary.wiley.com/doi....

Art

[JayPwP in reply to chartist]

Thanks

[park_bear in reply to JayPwP]

Seeking Health B Minus is a B complex without folate or B12 . I supplement B12 separately.

[JayPwP in reply to park_bear]

Thanks, but will it not drive up the folate requirements? Or is folate from diet sufficient?

I am not knowledgeable on B vitamins and their interplay

[park_bear in reply to JayPwP]

I have my folate and homocysteine levels checked whenever I get routine blood work done to make sure the former does not get too low and the latter does not get too high. So far has been okay, folate in the lower half of the normal range.

[JayPwP in reply to park_bear]

Thanks

[MBAnderson in reply to park_bear]

I'm holding off on Vitamin E judgement too, even tho I don't take it.

[Patrickk in reply to park_bear]

I take acytl-l carnitine to increase output of mitochondria -- and resveratrol to increase number of mitochondria.

I couldn't make out at all what he was saying was the harm of resveratrol (it's only wine skins).

[chartist]

Metformin does lower insulin resistance, FBG and HbA1c and it is one of the safer diabetic medications that doctors prescribe for diabetes, so it's not entirely horrible, but I consider berberine a better option worth considering for diabetics first.

Art

[JayPwP in reply to chartist]

Metformin's application in diabetes is proven, and also mentioned in the video.

The video questions Metformin's use as a longevity molecule

[chartist]

I thought that fallacy had been proven long ago.

He had mentioned that metformin also had a negative influence on exercise too, similarly to resveratrol.

Art

[JayPwP in reply to chartist]

As of 1 year ago, Sinclair was still pushing Resveratrol and Metformin as longevity molecules.

I guess that's what is being debunked here.

Personally I have no experience with Resveratrol or Metformin or Vitamin E

[chartist in reply to JayPwP]

Jay,

Take a look at the post I put up a little while ago.

Art

[JayPwP in reply to chartist]

Insulin resistance post or fmt post?

[chartist in reply to JayPwP]

FMT

[MarkPrana in reply to chartist]

The exercise impact of Resveratrol is concerning, have you come across any of the papers that published this link chartist ?

[chartist in reply to MarkPrana]

What I have read about resveratrol suggests it has a neutral to beneficial effect on exercise, but these are mainly animal studies such as this :

ncbi.nlm.nih.gov/pmc/articl...

A relevant study quote :

' Resveratrol supplementation could promote mitochondrial biosynthesis via the SIRT1/PGC-1α pathway, increase the activity of the mitochondrial energy metabolism-related enzymes, improve the antioxidant capacity of the body, and promote recovery from exercise-induced fatigue. '

Some of the studies he referenced to confirm his point were older and at that time it may have been questionable whether resveratrol was actually an activator of SIRT1. Had he used newer studies, that point would have been null.

Melatonin is also an activator of certain sirtuins including SIRT1 and is also beneficial for muscle tissue in relation to exercise as discussed here :

ncbi.nlm.nih.gov/pmc/articl...

Here is a relevant quote :

' Evidence shows that intense exercises disturb antioxidant status of competitive athletes, whereas supplementation with melatonin strengthens antioxidant status in trained athletes in various sports as the compound showed high potency in reduction of the oxidative stress and inflammation markers generated during intense and prolonged exercise. '

You might also be interested in Astaxanthin for use during exercise as I discussed here :

healthunlocked.com/cure-par...

Art

[MarkPrana in reply to chartist]

Thanks so much Art, exceptional insight as always 👍😀

[amykp]

What about pterostilbene? Anyone have an opinion on that? (Dang this stuff is confusing...)

[JayPwP in reply to amykp]

I have no idea

[Despe]

Read about E. Many people take tocopherols only. I found this E with all the tocopherols and tocotrienols. amazon.com/TrueE-Spectrum-V...

However, a good excuse to have hubby stop it.