Drugs that suppress immune system may protect against Parkinson’s
People taking corticosteroids such as prednisone were 20 percent less likely to be diagnosed with Parkinson's, while those on inosine monophosphate dehydrogenase (IMDH) inhibitors were about one-third less likely
medicine.wustl.edu/news/dru...
Accumulating epidemiological and clinical studies support a greater prevalence and incidence of Parkinson's disease (PD) in men than women, suggesting a potential contribution of sex hormones. Sex steroids can affect the brain (neuroactive steroids) and can also be synthesized in the brain (neurosteroids). Findings in PD patients and animal models of PD support a beneficial role of estrogen and progesterone, whereas androgens have not consistently shown beneficial or a deleterious effects. Estrogen and progesterone provide treatment options to be optimized including which estrogen/progesterone, the dose, duration and time of initiation of treatment. Drug modulating steroid synthetic pathways, pro-drugs, steroid precursors, brain selective estrogens, long-lasting formulations are promising treatments for precision hormonal therapy for PD in women and men, avoiding feminizing effects.